3CEK

Crystal structure of human dual specificity protein kinase (TTK)

Summary for 3CEK

Entry DOI	10.2210/pdb3cek/pdb
Descriptor	Dual specificity protein kinase TTK, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL (3 entities in total)
Functional Keywords	ttk, hmps1, pyt, esk, kinase, dual specificity, phosphotyrosine picked threonine kinase, sgc, structural genomics consortium, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	36736.03
Authors	Filippakopoulos, P.,Soundararajan, M.,Keates, T.,Elkins, J.M.,King, O.,Fedorov, O.,Picaud, S.S.,Pike, A.C.W.,Roos, A.,Pilka, E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-02-29, release date: 2008-03-18, Last modification date: 2023-08-30)
Primary citation	Kwiatkowski, N.,Jelluma, N.,Filippakopoulos, P.,Soundararajan, M.,Manak, M.S.,Kwon, M.,Choi, H.G.,Sim, T.,Deveraux, Q.L.,Rottmann, S.,Pellman, D.,Shah, J.V.,Kops, G.J.,Knapp, S.,Gray, N.S. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol., 6:359-368, 2010 Cited by PubMed: 20383151 DOI: 10.1038/nchembio.345 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation