2WO6

Human Dual-Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A in complex with a consensus substrate peptide

Summary for 2WO6

• Entry DOI: 10.2210/pdb2wo6/pdb
• Related: 2VX3
• Descriptor: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A, ARTIFICIAL CONSENSUS SEQUENCE, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide, ... (5 entities in total)
• Functional Keywords: transferase-peptide complex, transferase peptide complex, serine/threonine-protein atp-binding, phosphoprotein, nucleotide-binding, dyrk1, dyrk1a, kinase, nucleus, transferase, tyrosine-protein kinase, transferase/peptide
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus speckle: Q13627
• Total number of polymer chains: 3
• Total formula weight: 90820.57

Authors

Roos, A.K.,Soundararajan, M.,Elkins, J.M.,Fedorov, O.,Eswaran, J.,Phillips, C.,Pike, A.C.W.,Ugochukwu, E.,Muniz, J.R.C.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Wikstrom, M.,Edwards, A.,Bountra, C.,Knapp, S. (deposition date: 2009-07-22, release date: 2009-08-18, Last modification date: 2023-12-20)

• Primary citation: Soundararajan, M.,Roos, A.K.,Savitsky, P.,Filippakopoulos, P.,Kettenbach, A.N.,Olsen, J.V.,Gerber, S.A.,Eswaran, J.,Knapp, S.,Elkins, J.M.; Structures of Down Syndrome Kinases, Dyrks, Reveal Mechanisms of Kinase Activation and Substrate Recognition.; Structure, 21:986-, 2013; PubMed: 23665168; DOI: 10.1016/J.STR.2013.03.012

Experimental method

X-RAY DIFFRACTION (2.5 Å)