4AZE
Human DYRK1A in complex with Leucettine L41
Summary for 4AZE
Entry DOI | 10.2210/pdb4aze/pdb |
Related | 2VX3 2WO6 4AZF |
Descriptor | DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A, 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one (3 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus speckle: Q13627 |
Total number of polymer chains | 6 |
Total formula weight | 136142.56 |
Authors | Elkins, J.M.,Soundararajan, M.,Muniz, J.R.C.,Tahtouh, T.,Burgy, G.,Durieu, E.,Lozach, O.,Cochet, C.,Schmid, R.S.,Lo, D.C.,Delhommel, F.,Carreaux, F.,Bazureau, J.P.,Meijer, L.,Edwards, A.,Bountra, C.,Knapp, S. (deposition date: 2012-06-25, release date: 2012-09-05, Last modification date: 2023-12-20) |
Primary citation | Tahtouh, T.,Elkins, J.M.,Filippakopoulos, P.,Soundararajan, M.,Burgy, G.,Durieu, E.,Cochet, C.,Schmid, R.S.,Lo, D.C.,Delhommel, F.,Oberholzer, A.,Laurence, P.,Carreaux, F.,Bazureau, J.P.,Knapp, S.,Meijer, L. Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B. J.Med.Chem., 55:9312-, 2012 Cited by PubMed: 22998443DOI: 10.1021/JM301034U PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.15 Å) |
Structure validation
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