3K2L
Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2)
Summary for 3K2L
Entry DOI | 10.2210/pdb3k2l/pdb |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 2, SULFATE ION, SODIUM ION, ... (5 entities in total) |
Functional Keywords | dyrk2, dual-specificity tyrosine-(y)-phosphorylation regulated kinase 2, psk-h2, kinase, structural genomics consortium, sgc, apoptosis, atp-binding, magnesium, manganese, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q92630 |
Total number of polymer chains | 1 |
Total formula weight | 50046.88 |
Authors | Filippakopoulos, P.,Myrianthopoulos, V.,Soundararajan, M.,Krojer, T.,Hapka, E.,Fedorov, O.,Berridge, G.,Wang, J.,Shrestha, L.,Pike, A.C.W.,Ugochukwu, E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Mikros, E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-09-30, release date: 2009-10-13, Last modification date: 2023-11-22) |
Primary citation | Soundararajan, M.,Roos, A.K.,Savitsky, P.,Filippakopoulos, P.,Kettenbach, A.N.,Olsen, J.V.,Gerber, S.A.,Eswaran, J.,Knapp, S.,Elkins, J.M. Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition. Structure, 21:986-996, 2013 Cited by PubMed: 23665168DOI: 10.1016/j.str.2013.03.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.36 Å) |
Structure validation
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