3K2L

Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	ARG378
A	ASN381

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	ARG421
A	ASN425
A	ALA426

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 480

Chain	Residue
A	LYS284
A	GLN285
A	ARG288
A	GLY290

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 481

Chain	Residue
A	HIS174

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 482

Chain	Residue
A	ARG411
A	LYS413

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGQVVkAydhkvhqh..........VALK

Chain	Residue	Details
A	ILE155-LYS178

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHcDLKpeNILL

Chain	Residue	Details
A	ILE271-LEU283

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP275

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	ILE155
A	LYS178
A	PHE228

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by MAP3K10 => ECO:0000269|PubMed:18455992

Chain	Residue	Details
A	TPO308

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:22998443

Chain	Residue	Details
A	PTR309

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by ATM => ECO:0000269|PubMed:19965871

Chain	Residue	Details
A	SEP369

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAP3K10 => ECO:0000269|PubMed:18455992

Chain	Residue	Details
A	SER376

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	GLU279
A	ASP275

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	LYS277
A	ASP275

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site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	LYS277
A	ASP275
A	SER312

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site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASN280
A	LYS277
A	ASP275

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