4AZF

Human DYRK2 in complex with Leucettine L41

Summary for 4AZF

• Entry DOI: 10.2210/pdb4azf/pdb
• Related: 4AZE
• Descriptor: DYRK2 DUAL-SPECIFICITY TYROSINE-PHOSPHORYLATION REGULATED KINASE 2, 5-(1,3-benzodioxol-5-ylmethyl)-2-(phenylamino)-4H-imidazol-4-one, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: Q92630
• Total number of polymer chains: 1
• Total formula weight: 48751.70

Authors

Elkins, J.M.,Soundararajan, M.,Muniz, J.R.C.,Tahtouh, T.,Burgy, G.,Durieu, E.,Lozach, O.,Cochet, C.,Schmid, R.S.,Lo, D.C.,Delhommel, F.,Carreaux, F.,Bazureau, J.P.,Meijer, L.,Edwards, A.,Bountra, C.,Knapp, S. (deposition date: 2012-06-25, release date: 2012-09-05, Last modification date: 2023-12-20)

• Primary citation: Tahtouh, T.,Elkins, J.M.,Filippakopoulos, P.,Soundararajan, M.,Burgy, G.,Durieu, E.,Cochet, C.,Schmid, R.S.,Lo, D.C.,Delhommel, F.,Oberholzer, A.,Laurence, P.,Carreaux, F.,Bazureau, J.P.,Knapp, S.,Meijer, L.; Selectivity, Co-Crystal Structures and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.; J.Med.Chem., 55:9312-, 2012; PubMed: 22998443; DOI: 10.1021/JM301034U

Experimental method

X-RAY DIFFRACTION (2.55 Å)