2IHB
Crystal structure of the heterodimeric complex of human RGS10 and activated Gi alpha 3
Summary for 2IHB
Entry DOI | 10.2210/pdb2ihb/pdb |
Descriptor | Guanine nucleotide-binding protein G(k) subunit alpha, Regulator of G-protein signalling 10, TETRAFLUOROALUMINATE ION, ... (6 entities in total) |
Functional Keywords | g protein signalling, rgs, heterotrimeric g protein, signalling complex, structural genomics, structural genomics consortium, sgc, signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P08754 |
Total number of polymer chains | 2 |
Total formula weight | 55793.21 |
Authors | Soundararajan, M.,Turnbull, A.P.,Papagrigoriou, E.,Pike, A.C.W.,Bunkoczi, G.,Ugochukwu, E.,Gorrec, F.,von Delft, F.,Weigelt, J.,Edwards, A.,Arrowsmith, C.,Sundstrom, M.,Doyle, D.A.,Structural Genomics Consortium (SGC) (deposition date: 2006-09-26, release date: 2006-11-21, Last modification date: 2023-08-30) |
Primary citation | Soundararajan, M.,Willard, F.S.,Kimple, A.J.,Turnbull, A.P.,Ball, L.J.,Schoch, G.A.,Gileadi, C.,Fedorov, O.Y.,Dowler, E.F.,Higman, V.A.,Hutsell, S.Q.,Sundstrom, M.,Doyle, D.A.,Siderovski, D.P. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105:6457-6462, 2008 Cited by PubMed: 18434541DOI: 10.1073/pnas.0801508105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.71 Å) |
Structure validation
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