Author results

3CDU
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CRYSTAL STRUCTURE OF COXSACKIEVIRUS B3 RNA-DEPENDENT RNA POLYMERASE (3DPOL) IN COMPLEX WITH A PYROPHOSPHATE
Descriptor:RNA-directed RNA polymerase 3D-POL, CHLORIDE ION, SULFATE ION, ...
Authors:Gruez, A., Selisko, B., Roberts, M., Bricogne, G., Bussetta, C., Canard, B.
Deposit date:2008-02-27
Release date:2008-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases
J.Virol., 82, 2008
3CDW
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CRYSTAL STRUCTURE OF COXSACKIEVIRUS B3 RNA-DEPENDENT RNA POLYMERASE (3DPOL) IN COMPLEX WITH PROTEIN PRIMER VPG AND A PYROPHOSPHATE
Descriptor:RNA-directed RNA polymerase 3D-POL, Protein 3B, CHLORIDE ION, ...
Authors:Gruez, A., Selisko, B., Roberts, M., Bricogne, G., Bussetta, C., Canard, B.
Deposit date:2008-02-27
Release date:2008-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases
J.Virol., 82, 2008
1L9K
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DENGUE METHYLTRANSFERASE
Descriptor:RNA-DIRECTED RNA POLYMERASE, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Egloff, M.P., Benarroch, D., Selisko, B., Romette, J.L., Canard, B.
Deposit date:2002-03-25
Release date:2003-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
Embo J., 21, 2002
5M5B
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CRYSTAL STRUCTURE OF ZIKA VIRUS NS5 METHYLTRANSFERASE
Descriptor:NS5 methyltransferase, S-ADENOSYLMETHIONINE, SULFATE ION, ...
Authors:Barral, K., Ortiz Lombardia, M., Coutard, B., Decroly, E., Lichiere, J.
Deposit date:2016-10-21
Release date:2016-12-28
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
J. Virol., 91, 2017
4NYZ
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THE EMCV 3DPOL STRUCTURE WITH ALTERED MOTIF A CONFORMATION AT 2.15A RESOLUTION
Descriptor:Genome polyprotein, GLUTAMINE, MAGNESIUM ION, ...
Authors:Vives-adrian, L., Lujan, C., Ferrer-orta, C., Verdaguer, N.
Deposit date:2013-12-11
Release date:2014-03-19
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site
J.Virol., 88, 2014
4NZ0
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THE EMCV 3DPOL STRUCTURE AT 2.8A RESOLUTION
Descriptor:Genome polyprotein, GLYCEROL, CHLORIDE ION
Authors:Vives-adrian, L., Ferrer-orta, C., Verdaguer, N.
Deposit date:2013-12-11
Release date:2014-03-19
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site
J.Virol., 88, 2014
2QEQ
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CRYSTAL STRUCTURE OF KUNJIN VIRUS NS3 HELICASE
Descriptor:Flavivirin protease NS3 catalytic subunit
Authors:Milani, M., Mastrangelo, E., Bolognesi, M.
Deposit date:2007-06-26
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein
J.Mol.Biol., 372, 2007
3ELD
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WESSELSBRON METHYLTRANSFERASE IN COMPLEX WITH SINEFUNGIN
Descriptor:Methyltransferase, SINEFUNGIN, SULFATE ION
Authors:Bollati, M., Milani, M., Mastrangelo, E., Ricagno, S., Bolognesi, M.
Deposit date:2008-09-22
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELU
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOMET
Descriptor:Methyltransferase, S-ADENOSYLMETHIONINE, SULFATE ION
Authors:Bollati, M., Ricagno, S., Milani, M., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELW
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOMET AND GPPPG
Descriptor:Methyltransferase, SULFATE ION, S-ADENOSYLMETHIONINE, ...
Authors:Bollati, M., Ricagno, S., Milani, M., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELY
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOHCY
Descriptor:Methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Bollati, M., Milani, M., Ricagno, S., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-23
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3EMB
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH ADOMET AND 7MEGPPPG
Descriptor:Methyltransferase, S-ADENOSYLMETHIONINE, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, ...
Authors:Bollati, M., Ricagno, S., Milani, M., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-24
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3EMD
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WESSELSBRON VIRUS METHYLTRANSFERASE IN COMPLEX WITH SINEFUNGIN AND 7MEGPPPA
Descriptor:methyltransferase, SINEFUNGIN, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ...
Authors:Bollati, M., Milani, M., Ricagno, S., Mastrangelo, E., Bolognesi, M.
Deposit date:2008-09-24
Release date:2008-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
4Y2A
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CRYSTAL STRUCTURE OF COXSACKIE VIRUS B3 3D POLYMERASE IN COMPLEX WITH GPC-N114 INHIBITOR
Descriptor:3D polymerase, 2,2'-[(4-chlorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), SULFATE ION, ...
Authors:Vives-Adrian, L., Ferrer-Orta, C., Verdaguer, N.
Deposit date:2015-02-09
Release date:2015-04-01
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
4Y2C
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M300V 3D POLYMERASE MUTANT OF EMCV
Descriptor:Genome polyprotein, GLYCEROL
Authors:Verdaguer, N., Ferrer-Orta, C., Vives-Adrian, L.
Deposit date:2015-02-09
Release date:2015-04-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
4Y34
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CRYSTAL STRUCTURE OF COXSACKIEVIRUS B3 3D POLYMERASE IN COMPLEX WITH GPC-N143
Descriptor:3D polymerase, 2,2'-[(4-fluorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), SULFATE ION, ...
Authors:Vives-Adrian, L., Ferrer-Orta, C., Cerdaguer, N.
Deposit date:2015-02-10
Release date:2015-04-01
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
4Y3C
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I304V 3D POLYMERASE MUTANT OF EMCV
Descriptor:3D polymerase, GLYCEROL, CHLORIDE ION
Authors:Verdaguer, N., Ferrer-Orta, C., Vives-Adrian, L.
Deposit date:2015-02-10
Release date:2015-04-01
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
2HCN
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CRYSTAL STRUCTURE OF RNA DEPENDENT RNA POLYMERASE DOMAIN FROM WEST NILE VIRUS
Descriptor:RNA-directed RNA polymerase (NS5), CALCIUM ION, ZINC ION
Authors:Egloff, M.P., Malet, H., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-17
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
2HCS
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CRYSTAL STRUCTURE OF RNA DEPENDANT RNA POLYMERASE DOMAIN OF WEST NILE VIRUS
Descriptor:RNA-directed RNA polymerase (NS5), ZINC ION
Authors:Egloff, M.P., Malet, H., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-18
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
2HFZ
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CRYSTAL STRUCTURE OF RNA DEPENDENT RNA POLYMERASE DOMAIN FROM WEST NILE VIRUS
Descriptor:RNA-directed RNA polymerase(NS5), MAGNESIUM ION, ZINC ION
Authors:Egloff, M.P., Malet, H., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2006-06-26
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007
2OXT
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CRYSTAL STRUCTURE OF MEABAN VIRUS NUCLEOSIDE-2'-O-METHYLTRANSFERASE
Descriptor:NUCLEOSIDE-2'-O-METHYLTRANSFERASE, S-ADENOSYLMETHIONINE
Authors:Mastrangelo, E., Milani, M., Bollati, M., Bolognesi, M.
Deposit date:2007-02-21
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural bases for substrate recognition and activity in Meaban virus nucleoside-2'-O-methyltransferase
Protein Sci., 16, 2007
2P1D
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH GTP AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Egloff, M.P., Benarooch, D., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-05
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:An RNA cap (nucleoside-2'-O)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
EMBO J., 21, 2002
2P3L
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH GPPPA AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-09
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
2P3O
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH 7MEGPPPA AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-09
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.756 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
2P3Q
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CRYSTAL STRUCTURE OF DENGUE METHYLTRANSFERASE IN COMPLEX WITH GPPPG AND S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:type II methyltransferase, SULFATE ION, DIGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Egloff, M.P., Marseilles Structural Genomics Program @ AFMB (MSGP)
Deposit date:2007-03-09
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5
J.Mol.Biol., 372, 2007
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