Author results

4RIL
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STRUCTURE OF THE AMYLOID FORMING SEGMENT, GAVVTGVTAVA, FROM THE NAC DOMAIN OF PARKINSON'S DISEASE PROTEIN ALPHA-SYNUCLEIN, RESIDUES 68-78, DETERMINED BY ELECTRON DIFFRACTION
Descriptor:Alpha-synuclein
Authors:Rodriguez, J.A., Ivanova, M., Sawaya, M.R., Cascio, D., Reyes, F., Shi, D., Johnson, L., Guenther, E., Sangwan, S., Hattne, J., Nannenga, B., Brewster, A.S., Messerschmidt, M., Boutet, S., Sauter, N.K., Gonen, T., Eisenberg, D.S.
Deposit date:2014-10-06
Release date:2015-08-26
Last modified:2018-04-25
Method:ELECTRON CRYSTALLOGRAPHY (1.43 Å)
Cite:Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
4ZNN
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MICROED STRUCTURE OF THE SEGMENT, GVVHGVTTVA, FROM THE A53T FAMILIAL MUTANT OF PARKINSON'S DISEASE PROTEIN, ALPHA-SYNUCLEIN RESIDUES 47-56
Descriptor:Alpha-synuclein
Authors:Rodriguez, J.A., Ivanova, M., Sawaya, M.R., Cascio, D., Reyes, F., Shi, D., Johnson, L., Guenther, E., Sangwan, S., Hattne, J., Nannenga, B., Brewster, A.S., Messerschmidt, M., Boutet, S., Sauter, N.K., Gonen, T., Eisenberg, D.S.
Deposit date:2015-05-05
Release date:2015-09-09
Last modified:2017-09-06
Method:ELECTRON CRYSTALLOGRAPHY (1.41 Å)
Cite:Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
5VOS
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VGSNKGAIIGL FROM AMYLOID BETA DETERMINED BY MICROED
Descriptor:Amyloid beta A4 protein
Authors:Rodriguez, J.A., Sawaya, M.R., Cascio, D., Eisenberg, D.S., Griner, S.L., Gonen, T.
Deposit date:2017-05-03
Release date:2018-01-03
Last modified:2018-06-06
Method:ELECTRON CRYSTALLOGRAPHY (1.42 Å)
Cite:Common fibrillar spines of amyloid-beta and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
J. Biol. Chem., 293, 2018
1HLK
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METALLO-BETA-LACTAMASE FROM BACTEROIDES FRAGILIS IN COMPLEX WITH A TRICYCLIC INHIBITOR
Descriptor:BETA-LACTAMASE, TYPE II, ZINC ION, ...
Authors:Payne, D.J., Hueso-Rodriguez, J.A., Boyd, H., Concha, N.O., Janson, C.A., Gilpin, M., Bateson, J.H., Chever, C., Niconovich, N.L., Pearson, S., Rittenhouse, S., Tew, D., Diez, E., Perez, P., de la Fuente, J., Rees, M., Rivera-Sagredo, A.
Deposit date:2000-12-01
Release date:2001-11-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Identification of a series of tricyclic natural products as potent broad spectrum inhibitors of metallo-beta-lactamases
Antimicrob.Agents Chemother., 46, 2002
1OZT
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CRYSTAL STRUCTURE OF APO-H46R FAMILIAL ALS MUTANT HUMAN CU,ZN SUPEROXIDE DISMUTASE (CUZNSOD) TO 2.5A RESOLUTION
Descriptor:Superoxide dismutase [Cu-Zn]
Authors:Elam, J.S., Taylor, A.B., Strange, R., Antonyuk, S., Doucette, P.A., Rodriguez, J.A., Hasnain, S.S., Hayward, L.J., Valentine, J.S., Yeates, T.O., Hart, P.J.
Deposit date:2003-04-09
Release date:2003-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Amyloid-like Filaments and Water-filled Nanotubes Formed by SOD1 Mutant Proteins Linked to Familial ALS
Nat.Struct.Biol., 10, 2003
1OZU
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CRYSTAL STRUCTURE OF FAMILIAL ALS MUTANT S134N OF HUMAN CU,ZN SUPEROXIDE DISMUTASE (CUZNSOD) TO 1.3A RESOLUTION
Descriptor:Superoxide dismutase [Cu-Zn], ZINC ION, SULFATE ION
Authors:Elam, J.S., Taylor, A.B., Strange, R., Antonyuk, S., Doucette, P.A., Rodriguez, J.A., Hasnain, S.S., Hayward, L.J., Valentine, J.S., Yeates, T.O., Hart, P.J.
Deposit date:2003-04-09
Release date:2003-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Amyloid-like Filaments and Water-filled Nanotubes Formed by SOD1 Mutant Proteins Linked to Familial ALS
Nat.Struct.Biol., 10, 2003
1P1V
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CRYSTAL STRUCTURE OF FALS-ASSOCIATED HUMAN COPPER-ZINC SUPEROXIDE DISMUTASE (CUZNSOD) MUTANT D125H TO 1.4A
Descriptor:Superoxide dismutase [Cu-Zn], SULFATE ION, ZINC ION
Authors:Elam, J.S., Malek, K., Rodriguez, J.A., Doucette, P.A., Taylor, A.B., Hayward, L.J., Cabelli, D.E., Valentine, J.S., Hart, P.J.
Deposit date:2003-04-14
Release date:2003-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:An Alternative Mechanism of Bicarbonate-mediated Peroxidation by Copper-Zinc Superoxide Dismutase: RATES ENHANCED VIA PROPOSED ENZYME-ASSOCIATED PEROXYCARBONATE INTERMEDIATE
J.Biol.Chem., 278, 2003
1UXL
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I113T MUTANT OF HUMAN SOD1
Descriptor:SUPEROXIDE DISMUTASE [CU-ZN], COPPER (II) ION, ZINC ION, ...
Authors:Hough, M.A., Grossmann, J.G., Antonyuk, S.V., Strange, R.W., Doucette, P.A., Rodriguez, J.A., Whitson, L.J., Hart, P.J., Hayward, L.J., Valentine, J.S., Hasnain, S.S.
Deposit date:2004-02-25
Release date:2004-03-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Dimer Destabilization in Superoxide Dismutase May Result in Disease-Causing Properties: Structures of Motor Neuron Disease Mutants
Proc.Natl.Acad.Sci.USA, 101, 2004
1UXM
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A4V MUTANT OF HUMAN SOD1
Descriptor:SUPEROXIDE DISMUTASE [CU-ZN], COPPER (II) ION, ZINC ION
Authors:Hough, M.A., Grossmann, J.G., Antonyuk, S.V., Strange, R.W., Doucette, P.A., Rodriguez, J.A., Whitson, L.J., Hart, P.J., Hayward, L.J., Valentine, J.S., Hasnain, S.S.
Deposit date:2004-02-26
Release date:2004-03-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Dimer Destabilization in Superoxide Dismutase May Result in Disease-Causing Properties: Structures of Motor Neuron Disease Mutants
Proc.Natl.Acad.Sci.USA, 101, 2004
5FOY
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DE NOVO STRUCTURE OF THE BINARY MOSQUITO LARVICIDE BINAB AT PH 7
Descriptor:41.9 KDA INSECTICIDAL TOXIN, LARVICIDAL TOXIN 51 KDA PROTEIN
Authors:Colletier, J.P., Sawaya, M.R., Gingery, M., Rodriguez, J.A., Cascio, D., Brewster, A.S., Michels-Clark, T., Boutet, S., Williams, G.J., Messerschmidt, M., DePonte, D.P., Sierra, R.G., Laksmono, H., Koglin, J.E., Hunter, M.S., W Park, H., Uervirojnangkoorn, M., Bideshi, D.L., Brunger, A.T., Federici, B.A., Sauter, N.K., Eisenberg, D.S.
Deposit date:2015-11-26
Release date:2016-10-05
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure.
Nature, 539, 2016
5FOZ
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DE NOVO STRUCTURE OF THE BINARY MOSQUITO LARVICIDE BINAB AT PH 10
Descriptor:TOXIN, LARVICIDAL TOXIN PROTEIN, SODIUM ION
Authors:Colletier, J.P., Sawaya, M.R., Gingery, M., Rodriguez, J.A., Cascio, D., Brewster, A.S., Michels-Clark, T., Boutet, S., Williams, G.J., Messerschmidt, M., DePonte, D.P., Sierra, R.G., Laksmono, H., Koglin, J.E., Hunter, M.S., W Park, H., Uervirojnangkoorn, M., Bideshi, D.L., Brunger, A.T., Federici, B.A., Sauter, N.K., Eisenberg, D.S.
Deposit date:2015-11-26
Release date:2016-10-05
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure.
Nature, 539, 2016
5G37
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MR STRUCTURE OF THE BINARY MOSQUITO LARVICIDE BINAB AT PH 5
Descriptor:41.9 KDA INSECTICIDAL TOXIN, LARVICIDAL TOXIN 51 KDA PROTEIN
Authors:Colletier, J.P., Sawaya, M.R., Gingery, M., Rodriguez, J.A., Cascio, D., Brewster, A.S., Michels-Clark, T., Boutet, S., Williams, G.J., Messerschmidt, M., DePonte, D.P., Sierra, R.G., Laksmono, H., Koglin, J.E., Hunter, M.S., W Park, H., Uervirojnangkoorn, M., Bideshi, D.L., Brunger, A.T., Federici, B.A., Sauter, N.K., Eisenberg, D.S.
Deposit date:2016-04-24
Release date:2016-10-05
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure.
Nature, 539, 2016
5KNZ
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HUMAN ISLET AMYLOID POLYPEPTIDE SEGMENT 19-SGNNFGAILSS-29 WITH EARLY ONSET S20G MUTATION DETERMINED BY MICROED
Descriptor:hIAPP(residues 19-29)S20G
Authors:Krotee, P.A.L., Rodriguez, J.A., Sawaya, M.R., Cascio, D., Shi, D., Nannenga, B.L., Hattne, J., Reyes, F.E., Gonen, T., Eisenberg, D.S.
Deposit date:2016-06-28
Release date:2016-12-21
Last modified:2018-06-06
Method:ELECTRON CRYSTALLOGRAPHY (1.902 Å)
Cite:Human Islet Amyloid Polypeptide Segment 19-SGNNFGAILSS-29 with Early Onset S20G Mutation Determined by MicroED
To be Published
5KO0
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HUMAN ISLET AMYLOID POLYPEPTIDE SEGMENT 15-FLVHSSNNFGA-25 DETERMINED BY MICROED
Descriptor:hIAPP(15-25)WT, THIOCYANATE ION
Authors:Krotee, P.A.L., Rodriguez, J.A., Sawaya, M.R., Cascio, D., Shi, D., Nannenga, B.L., Hattne, J., Reyes, F.E., Gonen, T., Eisenberg, D.S.
Deposit date:2016-06-28
Release date:2016-12-21
Last modified:2018-06-06
Method:ELECTRON CRYSTALLOGRAPHY (1.4 Å)
Cite:Human Islet Amyloid Polypeptide Segment 15-FLVHSSNNFGA-25 Determined by MicroED
To be Published
5V5B
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KVQIINKKLD, STRUCTURE OF THE AMYLOID SPINE FROM MICROTUBULE ASSOCIATED PROTEIN TAU REPEAT 2
Descriptor:Microtubule-associated protein tau
Authors:Seidler, P.M., Sawaya, M.R., Rodriguez, J.A., Eisenberg, D.S., Cascio, D., Boyer, D.R.
Deposit date:2017-03-13
Release date:2018-02-07
Last modified:2018-06-06
Method:ELECTRON CRYSTALLOGRAPHY (1.5 Å)
Cite:Structure-based inhibitors of tau aggregation.
Nat Chem, 10, 2018
5V5C
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VQIINK, STRUCTURE OF THE AMYLOID-SPINE FROM MICROTUBULE ASSOCIATED PROTEIN TAU REPEAT 2
Descriptor:Microtubule-associated protein tau
Authors:Seidler, P.M., Sawaya, M.R., Rodriguez, J.A., Eisenberg, D.S., Cascio, D., Boyer, D.R.
Deposit date:2017-03-14
Release date:2018-02-07
Last modified:2018-06-06
Method:ELECTRON CRYSTALLOGRAPHY (1.25 Å)
Cite:Structure-based inhibitors of tau aggregation.
Nat Chem, 10, 2018
6AXZ
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SEGMENT FROM BANK VOLE PRION PROTEIN 168-176 QYNNQNNFV
Descriptor:Major prion protein
Authors:Glynn, C., Rodriguez, J.A., Boyer, D.R., Gallagher-Jones, M.
Deposit date:2017-09-07
Release date:2018-01-17
Last modified:2018-02-21
Method:ELECTRON CRYSTALLOGRAPHY (0.75 Å)
Cite:Sub-angstrom cryo-EM structure of a prion protofibril reveals a polar clasp.
Nat. Struct. Mol. Biol., 25, 2018
6BTK
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SEGMENT FROM BANK VOLE PRION PROTEIN 168-176 QYNNQNNFV
Descriptor:Major prion protein
Authors:Glynn, C., Rodriguez, J.A., Boyer, D.R., Gallagher-Jones, M.
Deposit date:2017-12-06
Release date:2018-01-17
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Sub-angstrom cryo-EM structure of a prion protofibril reveals a polar clasp.
Nat. Struct. Mol. Biol., 25, 2018
6BWZ
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SYSGYS FROM LOW-COMPLEXITY DOMAIN OF FUS, RESIDUES 37-42
Descriptor:SYSGYS peptide from low-complexity domain of FUS
Authors:Hughes, M.P., Rodriguez, J.A., Sawaya, M.R., Cascio, D., Tamir, G., Eisenberg, D.S.
Deposit date:2017-12-15
Release date:2018-04-04
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
6BXV
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SYSSYGQS FROM LOW-COMPLEXITY DOMAIN OF FUS, RESIDUES 54-61
Descriptor:FUS
Authors:Hughes, M.P., Rodriguez, J.A., Sawaya, M.R., Cascio, D., Gonen, T., Eisenberg, D.S.
Deposit date:2017-12-19
Release date:2018-04-04
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
6BXX
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GYNGFG FROM LOW-COMPLEXITY DOMAIN OF HNRNPA1, RESIDUES 243-248
Descriptor:hnRNPA1
Authors:Hughes, M.P., Rodriguez, J.A., Sawaya, M.R., Cascio, D., Gonen, T., Eisenberg, D.S.
Deposit date:2017-12-19
Release date:2018-04-04
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
6BZM
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GFGNFGTS FROM LOW-COMPLEXITY/FG REPEAT DOMAIN OF NUP98, RESIDUES 116-123
Descriptor:Nuclear pore complex protein Nup98-Nup96
Authors:Hughes, M.P., Rodriguez, J.A., Sawaya, M.R., Cascio, D., Chong, L., Gonen, T., Eisenberg, D.S.
Deposit date:2017-12-24
Release date:2018-04-04
Last modified:2018-04-25
Method:ELECTRON CRYSTALLOGRAPHY (0.9 Å)
Cite:Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
6BZP
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STGGYG FROM LOW-COMPLEXITY DOMAIN OF FUS, RESIDUES 77-82
Descriptor:RNA-binding protein FUS, 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL
Authors:Hughes, M.P., Rodriguez, J.A., Sawaya, M.R., Cascio, D., Gonen, T., Eisenberg, D.S.
Deposit date:2017-12-25
Release date:2018-04-04
Last modified:2018-04-25
Method:ELECTRON CRYSTALLOGRAPHY (1.1 Å)
Cite:Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
6CFH
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SWGMMGMLASQ SEGMENT FROM THE LOW COMPLEXITY DOMAIN OF TDP-43
Descriptor:SWGMMGMLASQ
Authors:Guenther, E.L., Rodriguez, J.A., Sawaya, M.R., Eisenberg, D.S.
Deposit date:2018-02-15
Release date:2018-05-23
Last modified:2018-06-13
Method:ELECTRON CRYSTALLOGRAPHY (1.5 Å)
Cite:Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
6CL7
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1.71 A MICROED STRUCTURE OF PROTEINASE K AT 0.86 E- / A^2
Descriptor:Proteinase K
Authors:Hattne, J., Shi, D., Glynn, C., Zee, C.-T., Gallagher-Jones, M., Martynowycz, M.W., Rodriguez, J.A., Gonen, T.
Deposit date:2018-03-02
Release date:2018-05-16
Method:ELECTRON CRYSTALLOGRAPHY (1.71 Å)
Cite:Analysis of Global and Site-Specific Radiation Damage in Cryo-EM.
Structure, 26, 2018
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