1P1V

Crystal Structure of FALS-associated human Copper-Zinc Superoxide Dismutase (CuZnSOD) Mutant D125H to 1.4A

Summary for 1P1V

Entry DOI	10.2210/pdb1p1v/pdb
Related	1AZV 1OEZ 1OZT 1OZU
Descriptor	Superoxide dismutase [Cu-Zn], SULFATE ION, ZINC ION, ... (4 entities in total)
Functional Keywords	beta-barrel, bound anion at copper site, cuznsod peroxidation mechanism, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00441
Total number of polymer chains	3
Total formula weight	48280.51
Authors	Elam, J.S.,Malek, K.,Rodriguez, J.A.,Doucette, P.A.,Taylor, A.B.,Hayward, L.J.,Cabelli, D.E.,Valentine, J.S.,Hart, P.J. (deposition date: 2003-04-14, release date: 2003-08-26, Last modification date: 2021-10-27)
Primary citation	Elam, J.S.,Malek, K.,Rodriguez, J.A.,Doucette, P.A.,Taylor, A.B.,Hayward, L.J.,Cabelli, D.E.,Valentine, J.S.,Hart, P.J. An Alternative Mechanism of Bicarbonate-mediated Peroxidation by Copper-Zinc Superoxide Dismutase: RATES ENHANCED VIA PROPOSED ENZYME-ASSOCIATED PEROXYCARBONATE INTERMEDIATE J.Biol.Chem., 278:21032-21039, 2003 Cited by PubMed: 12649272 DOI: 10.1074/jbc.M300484200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation