5VOS

VGSNKGAIIGL from Amyloid Beta determined by MicroED

Summary for 5VOS

• Entry DOI: 10.2210/pdb5vos/pdb
• Related: 5KNZ
• EMDB information: 8720
• Descriptor: Amyloid beta A4 protein (2 entities in total)
• Functional Keywords: amyloid, steric zipper, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 1029.21

Authors

Rodriguez, J.A.,Sawaya, M.R.,Cascio, D.,Eisenberg, D.S.,Griner, S.L.,Gonen, T. (deposition date: 2017-05-03, release date: 2018-01-03, Last modification date: 2024-03-13)

• Primary citation: Krotee, P.,Griner, S.L.,Sawaya, M.R.,Cascio, D.,Rodriguez, J.A.,Shi, D.,Philipp, S.,Murray, K.,Saelices, L.,Lee, J.,Seidler, P.,Glabe, C.G.,Jiang, L.,Gonen, T.,Eisenberg, D.S.; Common fibrillar spines of amyloid-beta and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.; J. Biol. Chem., 293:2888-2902, 2018; PubMed: 29282295; DOI: 10.1074/jbc.M117.806109

Experimental method

ELECTRON CRYSTALLOGRAPHY (1.42 Å)