1HLK

METALLO-BETA-LACTAMASE FROM BACTEROIDES FRAGILIS IN COMPLEX WITH A TRICYCLIC INHIBITOR

Summary for 1HLK

• Entry DOI: 10.2210/pdb1hlk/pdb
• Descriptor: BETA-LACTAMASE, TYPE II, ZINC ION, SODIUM ION, ... (5 entities in total)
• Functional Keywords: alpha-beta structure, beta-sandwich, hydrolase
• Biological source: Bacteroides fragilis
• Cellular location: Periplasm : P25910
• Total number of polymer chains: 2
• Total formula weight: 50560.04

Authors

Payne, D.J.,Hueso-Rodriguez, J.A.,Boyd, H.,Concha, N.O.,Janson, C.A.,Gilpin, M.,Bateson, J.H.,Chever, C.,Niconovich, N.L.,Pearson, S.,Rittenhouse, S.,Tew, D.,Diez, E.,Perez, P.,de la Fuente, J.,Rees, M.,Rivera-Sagredo, A. (deposition date: 2000-12-01, release date: 2001-11-30, Last modification date: 2023-08-09)

• Primary citation: Payne, D.J.,Hueso-Rodriguez, J.A.,Boyd, H.,Concha, N.O.,Janson, C.A.,Gilpin, M.,Bateson, J.H.,Chever, C.,Niconovich, N.L.,Pearson, S.,Rittenhouse, S.,Tew, D.,Diez, E.,Perez, P.,de la Fuente, J.,Rees, M.,Rivera-Sagredo, A.; Identification of a series of tricyclic natural products as potent broad spectrum inhibitors of metallo-beta-lactamases; Antimicrob.Agents Chemother., 46:1880-1886, 2002; PubMed: 12019104; DOI: 10.1128/AAC.46.6.1880-1886.2002

Experimental method

X-RAY DIFFRACTION (2.5 Å)