1HLK
METALLO-BETA-LACTAMASE FROM BACTEROIDES FRAGILIS IN COMPLEX WITH A TRICYCLIC INHIBITOR
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0008270 | molecular_function | zinc ion binding |
A | 0008800 | molecular_function | beta-lactamase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0017001 | biological_process | antibiotic catabolic process |
A | 0042597 | cellular_component | periplasmic space |
A | 0046677 | biological_process | response to antibiotic |
A | 0046872 | molecular_function | metal ion binding |
B | 0008270 | molecular_function | zinc ion binding |
B | 0008800 | molecular_function | beta-lactamase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0017001 | biological_process | antibiotic catabolic process |
B | 0042597 | cellular_component | periplasmic space |
B | 0046677 | biological_process | response to antibiotic |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1001 |
Chain | Residue |
A | HIS99 |
A | HIS101 |
A | HIS162 |
A | ZN1002 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 1002 |
Chain | Residue |
A | ASP103 |
A | CYS181 |
A | HIS223 |
A | ZN1001 |
A | 1132002 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN B 1003 |
Chain | Residue |
B | HIS99 |
B | HIS101 |
B | HIS162 |
B | 1132003 |
B | HOH2018 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN B 1004 |
Chain | Residue |
B | ASP103 |
B | CYS181 |
B | HIS223 |
B | 1132003 |
B | HOH2018 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA A 2001 |
Chain | Residue |
A | TYR40 |
A | ASN55 |
A | THR70 |
A | ASP103 |
A | HOH2016 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA B 2002 |
Chain | Residue |
B | SER54 |
B | ASN55 |
B | ASP69 |
B | THR70 |
B | ASP103 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE 113 A 2002 |
Chain | Residue |
A | ILE46 |
A | TRP49 |
A | CYS181 |
A | LYS184 |
A | ASN193 |
A | HIS223 |
A | ZN1002 |
site_id | AC8 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 113 B 2003 |
Chain | Residue |
B | TRP49 |
B | HIS162 |
B | CYS181 |
B | LYS184 |
B | SER190 |
B | ASN193 |
B | HIS223 |
B | ZN1003 |
B | ZN1004 |
B | HOH2018 |
B | HOH2037 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"10210203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12019104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8805566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9416622","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9545432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9578564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9761816","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"12019104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8805566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9416622","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9545432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9578564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9761816","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"9545432","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"12019104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9545432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9578564","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 2bmi |
Chain | Residue | Details |
A | ASP103 | |
A | ASN193 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 2bmi |
Chain | Residue | Details |
B | ASP103 | |
B | ASN193 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 2bmi |
Chain | Residue | Details |
A | ASP103 |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 2bmi |
Chain | Residue | Details |
B | ASP103 |
site_id | MCSA1 |
Number of Residues | 8 |
Details | M-CSA 15 |
Chain | Residue | Details |
A | HIS99 | metal ligand |
A | HIS101 | metal ligand |
A | ASP103 | metal ligand |
A | HIS162 | metal ligand |
A | CYS181 | metal ligand |
A | LYS184 | electrostatic stabiliser, steric role |
A | ASN193 | electrostatic stabiliser, hydrogen bond donor |
A | HIS223 | metal ligand |
site_id | MCSA2 |
Number of Residues | 8 |
Details | M-CSA 15 |
Chain | Residue | Details |
B | HIS99 | metal ligand |
B | HIS101 | metal ligand |
B | ASP103 | metal ligand |
B | HIS162 | metal ligand |
B | CYS181 | metal ligand |
B | LYS184 | electrostatic stabiliser, steric role |
B | ASN193 | electrostatic stabiliser, hydrogen bond donor |
B | HIS223 | metal ligand |