6AXZ
Segment from bank vole prion protein 168-176 QYNNQNNFV
Summary for 6AXZ
| Entry DOI | 10.2210/pdb6axz/pdb |
| EMDB information | 7017 |
| Descriptor | Major prion protein (2 entities in total) |
| Functional Keywords | polar clasp, amyloid fibril, prion, protein fibril |
| Biological source | Myodes glareolus (Bank vole) |
| Cellular location | Cell membrane ; Lipid-anchor, GPI-anchor : Q8VHV5 |
| Total number of polymer chains | 1 |
| Total formula weight | 1140.16 |
| Authors | Glynn, C.,Rodriguez, J.A.,Boyer, D.R.,Gallagher-Jones, M. (deposition date: 2017-09-07, release date: 2018-01-17, Last modification date: 2024-03-13) |
| Primary citation | Gallagher-Jones, M.,Glynn, C.,Boyer, D.R.,Martynowycz, M.W.,Hernandez, E.,Miao, J.,Zee, C.T.,Novikova, I.V.,Goldschmidt, L.,McFarlane, H.T.,Helguera, G.F.,Evans, J.E.,Sawaya, M.R.,Cascio, D.,Eisenberg, D.S.,Gonen, T.,Rodriguez, J.A. Sub-angstrom cryo-EM structure of a prion protofibril reveals a polar clasp. Nat. Struct. Mol. Biol., 25:131-134, 2018 Cited by PubMed Abstract: The atomic structure of the infectious, protease-resistant, β-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the sub-ångström-resolution structure of a protofibril formed by a wild-type segment from the β2-α2 loop of the bank vole prion protein. The structure of this protofibril reveals a stabilizing network of hydrogen bonds that link polar zippers within a sheet, producing motifs we have named 'polar clasps'. PubMed: 29335561DOI: 10.1038/s41594-017-0018-0 PDB entries with the same primary citation |
| Experimental method | ELECTRON CRYSTALLOGRAPHY (0.75 Å) |
Structure validation
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