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1B6Z
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BU of 1b6z by Molmil
6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE
Descriptor: 6-pyruvoyl tetrahydropterin synthase, ZINC ION
Authors:Ploom, T, Thoeny, B, Yim, J, Lee, S, Nar, H, Leimbacher, W, Huber, R, Richardson, J, Auerbach, G.
Deposit date:1999-01-18
Release date:2000-01-21
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.
J.Mol.Biol., 286, 1999
1B66
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BU of 1b66 by Molmil
6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE
Descriptor: 6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE, BIOPTERIN, ZINC ION
Authors:Ploom, T, Thoeny, B, Yim, J, Lee, S, Nar, H, Leimbacher, W, Huber, R, Richardson, J, Auerbach, G.
Deposit date:1999-01-20
Release date:1999-04-27
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.
J.Mol.Biol., 286, 1999
1B9L
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BU of 1b9l by Molmil
7,8-DIHYDRONEOPTERIN TRIPHOSPHATE EPIMERASE
Descriptor: PROTEIN (EPIMERASE)
Authors:Ploom, T, Haussmann, C, Hof, P, Steinbacher, S, Bacher, A, Richardson, J, Huber, R.
Deposit date:1999-02-11
Release date:2000-02-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of 7,8-dihydroneopterin triphosphate epimerase.
Structure Fold.Des., 7, 1999
1FBX
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BU of 1fbx by Molmil
CRYSTAL STRUCTURE OF ZINC-CONTAINING E.COLI GTP CYCLOHYDROLASE I
Descriptor: CHLORIDE ION, GTP CYCLOHYDROLASE I, ZINC ION
Authors:Auerbach, G, Herrmann, A, Bracher, A, Bader, A, Gutlich, M, Fischer, M, Neukamm, M, Nar, H, Garrido-Franco, M, Richardson, J, Huber, R, Bacher, A.
Deposit date:2000-07-17
Release date:2001-02-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Zinc plays a key role in human and bacterial GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FB1
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BU of 1fb1 by Molmil
CRYSTAL STRUCTURE OF HUMAN GTP CYCLOHYDROLASE I
Descriptor: GTP CYCLOHYDROLASE I, ISOPROPYL ALCOHOL, ZINC ION
Authors:Auerbach, G, Herrmann, A, Bracher, A, Bader, G, Gutlich, M, Fischer, M, Neukamm, M, Nar, H, Garrido-Franco, M, Richardson, J, Huber, R, Bacher, A.
Deposit date:2000-07-14
Release date:2000-12-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Zinc plays a key role in human and bacterial GTP cyclohydrolase I.
Proc.Natl.Acad.Sci.USA, 97, 2000
4ZCA
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BU of 4zca by Molmil
Eg5 motor domain mutant Y231F
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION
Authors:Luo, M, Parke, C, Worthylake, D.
Deposit date:2015-04-15
Release date:2016-06-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Eg5
To Be Published
4ZHI
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BU of 4zhi by Molmil
Eg5 motor domain mutant E162S
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11
Authors:Luo, M, Park, C, Worthylake, D, Kim, S.
Deposit date:2015-04-24
Release date:2016-06-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Eg5
To Be Published
6D1V
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BU of 6d1v by Molmil
Crystal structure of E. coli RppH-DapF complex, monomer bound to RNA
Descriptor: CHLORIDE ION, Diaminopimelate epimerase, GLYCEROL, ...
Authors:Gao, A, Serganov, A.
Deposit date:2018-04-12
Release date:2018-05-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF.
Nucleic Acids Res., 46, 2018
6D1Q
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BU of 6d1q by Molmil
Crystal structure of E. coli RppH-DapF complex, monomer
Descriptor: CHLORIDE ION, Diaminopimelate epimerase, GLYCEROL, ...
Authors:Gao, A, Serganov, A.
Deposit date:2018-04-12
Release date:2018-05-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF.
Nucleic Acids Res., 46, 2018
6D13
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BU of 6d13 by Molmil
Crystal structure of E.coli RppH-DapF complex
Descriptor: CHLORIDE ION, Diaminopimelate epimerase, IODIDE ION, ...
Authors:Gao, A, Serganov, A.
Deposit date:2018-04-11
Release date:2018-05-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF.
Nucleic Acids Res., 46, 2018
2VA8
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BU of 2va8 by Molmil
DNA Repair Helicase Hel308
Descriptor: SKI2-TYPE HELICASE, SULFATE ION
Authors:Johnson, K.A, Richards, J, Liu, H, McMahon, S, Oke, M, Carter, L, Naismith, J.H, White, M.F.
Deposit date:2007-08-30
Release date:2008-01-15
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the DNA Repair Helicase Hel308 Reveals DNA Binding and Autoinhibitory Domains.
J.Biol.Chem., 283, 2008
3KEN
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BU of 3ken by Molmil
Human Eg5 in complex with S-trityl-L-cysteine
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ...
Authors:Parke, C.L, Wojcik, E.J, Kim, S, Worthylake, D.K.
Deposit date:2009-10-26
Release date:2010-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.
J.Biol.Chem., 285, 2010
6ONE
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BU of 6one by Molmil
Crystal structure of HIV-1 LM/HT Clade A/E CRF01 gp120 core in complex with (S)-MCG-III-188-A01.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, clade A/E 93TH057 HIV-1 gp120 core, ...
Authors:Tolbert, W.D, Sherburn, R, Pazgier, M.
Deposit date:2019-04-22
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity.
J.Virol., 93, 2019
6ONH
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BU of 6onh by Molmil
Crystal structure of HIV-1 LM/HT Clade A/E CRF01 gp120 core in complex with (S)-MCG-IV-031-A05.
Descriptor: (3S)-N~3~-(4-chloro-3-fluorophenyl)-N~1~-propylpiperidine-1,3-dicarboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Tolbert, W.D, Sherburn, R, Pazgier, M.
Deposit date:2019-04-22
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.244 Å)
Cite:A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity.
J.Virol., 93, 2019
6ONV
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BU of 6onv by Molmil
Crystal structure of HIV-1 LM/HT Clade A/E CRF01 gp120 core in complex with (S)-MCG-III-027-D05.
Descriptor: (3S)-N-(4-chloro-3-fluorophenyl)-1-(methylsulfonyl)piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Tolbert, W.D, Sherburn, R, Pazgier, M.
Deposit date:2019-04-22
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.253 Å)
Cite:A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity.
J.Virol., 93, 2019
6ONF
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BU of 6onf by Molmil
Crystal structure of HIV-1 LM/HT Clade A/E CRF01 gp120 core in complex with (S)-MCG-III-188-A02.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, clade A/E 93TH057 HIV-1 gp120 core, ...
Authors:Tolbert, W.D, Sherburn, R, Pazgier, M.
Deposit date:2019-04-22
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.842 Å)
Cite:A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity.
J.Virol., 93, 2019
6P9N
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BU of 6p9n by Molmil
CRYSTAL STRUCTURE OF HIV-1 LM/HT CLADE A/E CRF01 GP120 CORE IN COMPLEX WITH (S)-MCG-IV-210.
Descriptor: (3S)-N~1~-(2-aminoethyl)-N~3~-(4-chloro-3-fluorophenyl)piperidine-1,3-dicarboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Tolbert, W.D, Sherburn, R, Pazgier, M.
Deposit date:2019-06-10
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A New Family of Small-Molecule CD4-Mimetic Compounds Contacts Highly Conserved Aspartic Acid 368 of HIV-1 gp120 and Mediates Antibody-Dependent Cellular Cytotoxicity.
J.Virol., 93, 2019
6VSL
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BU of 6vsl by Molmil
Crystal structure of a human fucosylated IgG1 Fc expressed in tobacco plants (Nicotiana benthamiana)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2020-02-11
Release date:2021-02-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Enhanced Ability of Plant-Derived PGT121 Glycovariants To Eliminate HIV-1-Infected Cells.
J.Virol., 95, 2021
6VSZ
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BU of 6vsz by Molmil
Crystal structure of a human afucosylated IgG1 Fc expressed in tobacco plants (Nicotiana benthamiana)
Descriptor: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2020-02-12
Release date:2021-02-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Enhanced Ability of Plant-Derived PGT121 Glycovariants To Eliminate HIV-1-Infected Cells.
J.Virol., 95, 2021
7NAB
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BU of 7nab by Molmil
Crystal structure of human neutralizing mAb CV3-25 binding to SARS-CoV-2 S MPER peptide 1140-1165
Descriptor: CITRIC ACID, CV3-25 Fab Heavy Chain, CV3-25 Fab Light Chain, ...
Authors:Chen, Y, Tolbert, W.D, Pazgier, M.
Deposit date:2021-06-21
Release date:2021-12-08
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern.
Cell Rep, 38, 2022
8DCQ
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BU of 8dcq by Molmil
CRYSTAL STRUCTURE OF HIV-1 LM/HT CLADE A/E CRF01 GP120 CORE IN COMPLEX WITH YIR-821
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 LM/HT Clade A/E CRF01 gp120 core, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2022-06-17
Release date:2023-01-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates.
J.Virol., 97, 2023
7RQ6
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BU of 7rq6 by Molmil
Cryo-EM structure of SARS-CoV-2 spike in complex with non-neutralizing NTD-directed CV3-13 Fab isolated from convalescent individual
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CV3-13 Fab heavy chain, ...
Authors:Chen, Y, Pozharski, E, Tolbert, W.D, Pazgier, M.
Deposit date:2021-08-05
Release date:2022-04-20
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection.
Cell Rep, 38, 2022
8A46
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BU of 8a46 by Molmil
Crystal structure of the human Kelch domain of Keap1 in complex with compound S217879
Descriptor: 2-[(1S,2R,8S)-2,4,32-trimethyl-28,28-bis(oxidanylidene)-19,22,27-trioxa-28$l^{6}-thia-1,14,15,16-tetrazahexacyclo[21.5.3.1^{3,7}.1^{9,13}.0^{12,16}.0^{26,30}]tritriaconta-3(33),4,6,9(32),10,12,14,23,25,30-decaen-8-yl]ethanoic acid, Kelch-like ECH-associated protein 1
Authors:Weber, C, Vuillard, L, Delerive, P, Miallau, L.
Deposit date:2022-06-10
Release date:2022-07-13
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.323 Å)
Cite:Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice.
JHEP Rep, 5, 2023
7TJP
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BU of 7tjp by Molmil
HIV-1 gp120 complex with CJF-II-195
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, IMIDAZOLE, ...
Authors:Gong, Z, Hendrickson, W.A.
Deposit date:2022-01-16
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines
Acs Medicinal Chemistry Letters, 14, 2023
7TJO
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BU of 7tjo by Molmil
HIV-1 gp120 complex with CJF-II-197-S
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, IMIDAZOLE, ...
Authors:Gong, Z, Hendrickson, W.A.
Deposit date:2022-01-16
Release date:2023-01-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines
ACS Medicinal Chemistry Letters, 14, 2023

 

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