8DCQ

CRYSTAL STRUCTURE OF HIV-1 LM/HT CLADE A/E CRF01 GP120 CORE IN COMPLEX WITH YIR-821

Summary for 8DCQ

• Entry DOI: 10.2210/pdb8dcq/pdb
• Descriptor: HIV-1 LM/HT Clade A/E CRF01 gp120 core, 2-acetamido-2-deoxy-beta-D-glucopyranose, N~1~-{(3R)-1-[2-(5-carbamimidamidopentanamido)ethyl]-1-azaspiro[5.5]undecan-3-yl}-N~2~-(4-chlorophenyl)ethanediamide, ... (4 entities in total)
• Functional Keywords: hiv-1 gp120, clade a/e cf01, viral protein, viral protein-inhibitor complex
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 42451.23

Authors

Tolbert, W.D.,Pazgier, M. (deposition date: 2022-06-17, release date: 2023-01-11, Last modification date: 2023-10-25)

• Primary citation: Matsumoto, K.,Kuwata, T.,Tolbert, W.D.,Richard, J.,Ding, S.,Prevost, J.,Takahama, S.,Judicate, G.P.,Ueno, T.,Nakata, H.,Kobayakawa, T.,Tsuji, K.,Tamamura, H.,Smith 3rd, A.B.,Pazgier, M.,Finzi, A.,Matsushita, S.; Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates.; J.Virol., 97:e0163822-e0163822, 2023; PubMed: 36511698; DOI: 10.1128/jvi.01638-22

Experimental method

X-RAY DIFFRACTION (3.2 Å)