6VSZ

Crystal structure of a human afucosylated IgG1 Fc expressed in tobacco plants (Nicotiana benthamiana)

Summary for 6VSZ

• Entry DOI: 10.2210/pdb6vsz/pdb
• Descriptor: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: immune system, immunoglobulin, crystallizable fragment, igg1, fc
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 50794.78

Authors

Tolbert, W.D.,Pazgier, M. (deposition date: 2020-02-12, release date: 2021-02-17, Last modification date: 2023-10-11)

• Primary citation: Anand, S.P.,Ding, S.,Tolbert, W.D.,Prevost, J.,Richard, J.,Gil, H.M.,Gendron-Lepage, G.,Cheung, W.F.,Wang, H.,Pastora, R.,Saxena, H.,Wakarchuk, W.,Medjahed, H.,Wines, B.D.,Hogarth, M.,Shaw, G.M.,Martin, M.A.,Burton, D.R.,Hangartner, L.,Evans, D.T.,Pazgier, M.,Cossar, D.,McLean, M.D.,Finzi, A.; Enhanced Ability of Plant-Derived PGT121 Glycovariants To Eliminate HIV-1-Infected Cells.; J.Virol., 95:e0079621-e0079621, 2021; PubMed: 34232070; DOI: 10.1128/JVI.00796-21

Experimental method

X-RAY DIFFRACTION (2.6 Å)