3KEN

Human Eg5 in complex with S-trityl-L-cysteine

Summary for 3KEN

Entry DOI	10.2210/pdb3ken/pdb
Related	1II6 1X88 2WOG 3HQD
Descriptor	Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, S-TRITYL-L-CYSTEINE, ... (6 entities in total)
Functional Keywords	cell cycle, kinesin-inhibitor complex, motor domain, l5 loop, atp-binding, cell division, coiled coil, microtubule, mitosis, motor protein, nucleotide-binding, phosphoprotein
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P52732
Total number of polymer chains	1
Total formula weight	42042.83
Authors	Parke, C.L.,Wojcik, E.J.,Kim, S.,Worthylake, D.K. (deposition date: 2009-10-26, release date: 2010-03-16, Last modification date: 2023-09-06)
Primary citation	Kim, E.D.,Buckley, R.,Learman, S.,Richard, J.,Parke, C.,Worthylake, D.K.,Wojcik, E.J.,Walker, R.A.,Kim, S. Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core. J.Biol.Chem., 285:18650-18661, 2010 Cited by PubMed: 20299460 DOI: 10.1074/jbc.M109.092072 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation