7NAB

Crystal structure of human neutralizing mAb CV3-25 binding to SARS-CoV-2 S MPER peptide 1140-1165

Summary for 7NAB

• Entry DOI: 10.2210/pdb7nab/pdb
• Descriptor: CV3-25 Fab Heavy Chain, CV3-25 Fab Light Chain, Spike protein S2, ... (6 entities in total)
• Functional Keywords: human neutralizing mab, mper-targeting, sars-cov-2, spike, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 101894.91

Authors

Chen, Y.,Tolbert, W.D.,Pazgier, M. (deposition date: 2021-06-21, release date: 2021-12-08, Last modification date: 2024-04-03)

• Primary citation: Li, W.,Chen, Y.,Prevost, J.,Ullah, I.,Lu, M.,Gong, S.Y.,Tauzin, A.,Gasser, R.,Vezina, D.,Anand, S.P.,Goyette, G.,Chaterjee, D.,Ding, S.,Tolbert, W.D.,Grunst, M.W.,Bo, Y.,Zhang, S.,Richard, J.,Zhou, F.,Huang, R.K.,Esser, L.,Zeher, A.,Cote, M.,Kumar, P.,Sodroski, J.,Xia, D.,Uchil, P.D.,Pazgier, M.,Finzi, A.,Mothes, W.; Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern.; Cell Rep, 38:110210-110210, 2022; PubMed: 34971573; DOI: 10.1016/j.celrep.2021.110210

Experimental method

X-RAY DIFFRACTION (2.15 Å)