7RQ6
Cryo-EM structure of SARS-CoV-2 spike in complex with non-neutralizing NTD-directed CV3-13 Fab isolated from convalescent individual
Summary for 7RQ6
Entry DOI | 10.2210/pdb7rq6/pdb |
EMDB information | 24628 |
Descriptor | Spike glycoprotein, CV3-13 Fab heavy chain, CV3-13 Fab light chain, ... (5 entities in total) |
Functional Keywords | human non-neutralizing mab, ntd-directed antibody, adcc, novel ntd epitope, sars-cov-2, spike, n-terminal domain, viral protein-immune system complex, viral protein/immune system |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2) More |
Total number of polymer chains | 9 |
Total formula weight | 565520.07 |
Authors | Chen, Y.,Pozharski, E.,Tolbert, W.D.,Pazgier, M. (deposition date: 2021-08-05, release date: 2022-04-20, Last modification date: 2023-08-09) |
Primary citation | Beaudoin-Bussieres, G.,Chen, Y.,Ullah, I.,Prevost, J.,Tolbert, W.D.,Symmes, K.,Ding, S.,Benlarbi, M.,Gong, S.Y.,Tauzin, A.,Gasser, R.,Chatterjee, D.,Vezina, D.,Goyette, G.,Richard, J.,Zhou, F.,Stamatatos, L.,McGuire, A.T.,Charest, H.,Roger, M.,Pozharski, E.,Kumar, P.,Mothes, W.,Uchil, P.D.,Pazgier, M.,Finzi, A. A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection. Cell Rep, 38:110368-110368, 2022 Cited by PubMed: 35123652DOI: 10.1016/j.celrep.2022.110368 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.18 Å) |
Structure validation
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