Author results

6AXK
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CRYSTAL STRUCTURE OF FAB311 COMPLEX
Descriptor:Fab311 heavy chain, Fab311 light chain, ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN, ...
Authors:Oyen, D., Wilson, I.A.
Deposit date:2017-09-07
Release date:2017-11-22
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6AXL
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CRYSTAL STRUCTURE OF FAB317 COMPLEX
Descriptor:Fab317 light chains, Fab317 heavy chain, Peptide ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-NH2
Authors:Oyen, D., Wilson, I.A.
Deposit date:2017-09-07
Release date:2017-11-22
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3K74
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DISRUPTION OF PROTEIN DYNAMICS BY AN ALLOSTERIC EFFECTOR ANTIBODY
Descriptor:Dihydrofolate reductase, Nanobody
Authors:Oyen, D., Srinivasan, V., Steyaert, J., Barlow, J.
Deposit date:2009-10-12
Release date:2010-10-20
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.
J.Mol.Biol., 407, 2011
4EIG
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CA1698 CAMEL ANTIBODY FRAGMENT IN COMPLEX WITH DHFR
Descriptor:Dihydrofolate reductase, CA1698 camel antibody fragment
Authors:Oyen, D., Srinivasan, V.
Deposit date:2012-04-05
Release date:2013-04-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4EIZ
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STRUCTURE OF NB113 BOUND TO APODHFR
Descriptor:Dihydrofolate reductase, Nb113 Camel antibody fragment
Authors:Oyen, D., Srinivasan, V.
Deposit date:2012-04-06
Release date:2013-04-24
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4EJ1
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BINDING OF NB113 CAMELID ANTIBODY FRAGMENT WITH THE BINARY DHFR:FOLATE COMPLEX
Descriptor:Dihydrofolate reductase, Nb113 camelid antibody fragment, FOLIC ACID, ...
Authors:Oyen, D., Srinivasan, V.
Deposit date:2012-04-06
Release date:2013-04-24
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4FHB
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ENHANCING DHFR CATALYSIS BY BINDING OF AN ALLOSTERIC REGULATOR NANOBODY (NB179)
Descriptor:Dihydrofolate reductase, Nb179, FOLIC ACID, ...
Authors:Oyen, D.
Deposit date:2012-06-06
Release date:2013-04-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4I13
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NANOBODY CA1697 BINDING TO THE DHFR.FOLATE BINARY COMPLEX
Descriptor:Dihydrofolate reductase, Protein ca1697 (nanobody), FOLIC ACID
Authors:Oyen, D., Steyaert, J., Barlow, J.N.
Deposit date:2012-11-19
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Exploring an alternative antibody interaction mechanism
To be Published
4I1N
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R104A-CA1697 NANOBODY BINDING TO THE BINARY DHFR.FOLATE COMPLEX
Descriptor:Dihydrofolate reductase, Protein ca1697 (nanobody), FOLIC ACID
Authors:Oyen, D., Steyaert, J., Barlow, J.N.
Deposit date:2012-11-21
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.888 Å)
Cite:Exploring an alternative antibody interaction mechanism
To be Published
5CC9
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L28F E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE
Descriptor:Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5,10-DIDEAZATETRAHYDROFOLIC ACID
Authors:Oyen, D., Wright, P.E.
Deposit date:2015-07-01
Release date:2015-08-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.199 Å)
Cite:Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.
J.Am.Chem.Soc., 137, 2015
5CCC
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WILD-TYPE E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE
Descriptor:Dihydrofolate reductase, 5,10-DIDEAZATETRAHYDROFOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oyen, D., Wright, P.E.
Deposit date:2015-07-01
Release date:2015-08-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.
J.Am.Chem.Soc., 137, 2015
5W3Q
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L28F E.COLI DHFR IN COMPLEX WITH NADPH
Descriptor:Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION
Authors:Oyen, D., Wright, P.E., Wilson, I.A.
Deposit date:2017-06-08
Release date:2017-08-09
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion.
J. Am. Chem. Soc., 139, 2017
6BQB
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MGG4 FAB IN COMPLEX WITH PEPTIDE
Descriptor:MGG4 Fab light chain, MGG4 Fab heavy chain, N-terminal junction peptide, ...
Authors:Oyen, D., Tan, J., Lanzavecchia, A., Wilson, I.A.
Deposit date:2017-11-27
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.
Nat. Med., 24, 2018
6CJK
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ANTI HIV FAB 10A
Descriptor:Immunoglobulin Fab light chain, Immunoglobulin Fab heavy chain, ACETATE ION, ...
Authors:Hangartner, L., Ward, A.B., Wilson, I.A., Oyen, D.
Deposit date:2018-02-26
Release date:2018-08-15
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (1.795 Å)
Cite:Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization.
Immunity, 49, 2018
6DID
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HIV ENV BG505 SOSIP WITH POLYCLONAL FABS FROM IMMUNIZED RABBIT #3417 POST-BOOST#1
Descriptor:Envelope glycoprotein gp160, Monoclonal antibody 10A light chain, Monoclonal antibody 10A heavy chain, ...
Authors:Turner, H.L., Cottrell, C.A., Oyen, D., Wilson, I.A., Ward, A.B.
Deposit date:2018-05-23
Release date:2018-09-05
Method:ELECTRON MICROSCOPY (4.71 Å)
Cite:Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization.
Immunity, 49, 2018
6MB3
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CRYO-EM STRUCTURE OF THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM FALCIPARUM WITH A VACCINE-ELICITED ANTIBODY REVEALS MATURATION OF INTER-ANTIBODY CONTACTS
Descriptor:Plasmodium falciparum recombinant shortened CSP, Fab311 heavy chain, Fab311 light chain
Authors:Cottrell, C.A., Torres, J.L., Ward, A.B.
Deposit date:2018-08-29
Release date:2018-10-31
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Cryo-EM structure ofP. falciparumcircumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts.
Sci Adv, 4, 2018
6MHG
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CRYO-EM STRUCTURE OF THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM FALCIPARUM WITH A VACCINE-ELICITED ANTIBODY REVEALS MATURATION OF INTER-ANTIBODY CONTACTS
Descriptor:circumsporozoite protein, Fab311 heavy chain, Fab311 light chain
Authors:Cottrell, C.A., Torres, J.L., Ward, A.B.
Deposit date:2018-09-17
Release date:2018-10-31
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Cryo-EM structure ofP. falciparumcircumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts.
Sci Adv, 4, 2018
6AOP
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CRYSTAL STRUCTURE OF THE A/BRISBANE/10/2007 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ L194P MUTANT APO FORM
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wu, N.C., Wilson, I.A.
Deposit date:2017-08-16
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.
PLoS Pathog., 13, 2017
6AOQ
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CRYSTAL STRUCTURE OF THE A/BRISBANE/10/2007 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ APO FORM
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wu, N.C., Wilson, I.A.
Deposit date:2017-08-16
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.
PLoS Pathog., 13, 2017
6AOR
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CRYSTAL STRUCTURE OF THE A/BRISBANE/10/2007 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ APO FORM
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wu, N.C., Wilson, I.A.
Deposit date:2017-08-16
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.
PLoS Pathog., 13, 2017
6AOS
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CRYSTAL STRUCTURE OF THE A/BRISBANE/10/2007 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ L194P MUTANT IN COMPLEX WITH 3'-SLNLN
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wu, N.C., Wilson, I.A.
Deposit date:2017-08-16
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.
PLoS Pathog., 13, 2017
6AOT
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CRYSTAL STRUCTURE OF THE A/BRISBANE/10/2007 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ L194P MUTANT IN COMPLEX WITH 6'-SLNLN
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wu, N.C., Wilson, I.A.
Deposit date:2017-08-16
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.
PLoS Pathog., 13, 2017
6AOU
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CRYSTAL STRUCTURE OF THE A/BRISBANE/10/2007 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH 3'-SLNLN
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wu, N.C., Wilson, I.A.
Deposit date:2017-08-16
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.
PLoS Pathog., 13, 2017
6AOV
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CRYSTAL STRUCTURE OF THE A/BRISBANE/10/2007 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH 6'-SLNLN
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Wu, N.C., Wilson, I.A.
Deposit date:2017-08-16
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.
PLoS Pathog., 13, 2017