Author results

6AXK
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CRYSTAL STRUCTURE OF FAB311 COMPLEX
Descriptor:Fab311 heavy chain, Fab311 light chain, ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN, ...
Authors:Oyen, D., Wilson, I.A.
Deposit date:2017-09-07
Release date:2017-11-22
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6AXL
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CRYSTAL STRUCTURE OF FAB317 COMPLEX
Descriptor:Fab317 light chains, Fab317 heavy chain, Peptide ACE-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-ASN-PRO-ASN-ALA-NH2
Authors:Oyen, D., Wilson, I.A.
Deposit date:2017-09-07
Release date:2017-11-22
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6PBV
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CRYSTAL STRUCTURE OF FAB668 COMPLEX
Descriptor:Fab668 light chain, Fab668 heavy chain, Junctional peptide, ...
Authors:Oyen, D., Wilson, I.A.
Deposit date:2019-06-14
Release date:2020-03-04
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (1.566 Å)
Cite:Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
Plos Pathog., 16, 2020
6PBW
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CRYSTAL STRUCTURE OF FAB667 COMPLEX
Descriptor:Fab667 light chain, Fab667 heavy chain, NPNANPNANPNA peptide, ...
Authors:Oyen, D., Wilson, I.A.
Deposit date:2019-06-14
Release date:2020-03-04
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (2.058 Å)
Cite:Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.
Plos Pathog., 16, 2020
3K74
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DISRUPTION OF PROTEIN DYNAMICS BY AN ALLOSTERIC EFFECTOR ANTIBODY
Descriptor:Dihydrofolate reductase, Nanobody
Authors:Oyen, D., Srinivasan, V., Steyaert, J., Barlow, J.
Deposit date:2009-10-12
Release date:2010-10-20
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.
J.Mol.Biol., 407, 2011
4EIG
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CA1698 CAMEL ANTIBODY FRAGMENT IN COMPLEX WITH DHFR
Descriptor:Dihydrofolate reductase, CA1698 camel antibody fragment
Authors:Oyen, D., Srinivasan, V.
Deposit date:2012-04-05
Release date:2013-04-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4EIZ
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STRUCTURE OF NB113 BOUND TO APODHFR
Descriptor:Dihydrofolate reductase, Nb113 Camel antibody fragment
Authors:Oyen, D., Srinivasan, V.
Deposit date:2012-04-06
Release date:2013-04-24
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4EJ1
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BINDING OF NB113 CAMELID ANTIBODY FRAGMENT WITH THE BINARY DHFR:FOLATE COMPLEX
Descriptor:Dihydrofolate reductase, Nb113 camelid antibody fragment, FOLIC ACID, ...
Authors:Oyen, D., Srinivasan, V.
Deposit date:2012-04-06
Release date:2013-04-24
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4FHB
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ENHANCING DHFR CATALYSIS BY BINDING OF AN ALLOSTERIC REGULATOR NANOBODY (NB179)
Descriptor:Dihydrofolate reductase, Nb179, FOLIC ACID, ...
Authors:Oyen, D.
Deposit date:2012-06-06
Release date:2013-04-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli.
Biochim.Biophys.Acta, 1834, 2013
4I13
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NANOBODY CA1697 BINDING TO THE DHFR.FOLATE BINARY COMPLEX
Descriptor:Dihydrofolate reductase, Protein ca1697 (nanobody), FOLIC ACID
Authors:Oyen, D., Steyaert, J., Barlow, J.N.
Deposit date:2012-11-19
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Exploring an alternative antibody interaction mechanism
To be Published
4I1N
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R104A-CA1697 NANOBODY BINDING TO THE BINARY DHFR.FOLATE COMPLEX
Descriptor:Dihydrofolate reductase, Protein ca1697 (nanobody), FOLIC ACID
Authors:Oyen, D., Steyaert, J., Barlow, J.N.
Deposit date:2012-11-21
Release date:2013-11-27
Method:X-RAY DIFFRACTION (1.888 Å)
Cite:Exploring an alternative antibody interaction mechanism
To be Published
5CC9
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L28F E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE
Descriptor:Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5,10-DIDEAZATETRAHYDROFOLIC ACID
Authors:Oyen, D., Wright, P.E.
Deposit date:2015-07-01
Release date:2015-08-05
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.199 Å)
Cite:Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.
J.Am.Chem.Soc., 137, 2015
5CCC
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WILD-TYPE E.COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH 5,10-DIDEAZATETRAHYDROFOLATE AND OXIDIZED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE
Descriptor:Dihydrofolate reductase, 5,10-DIDEAZATETRAHYDROFOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Oyen, D., Wright, P.E.
Deposit date:2015-07-01
Release date:2015-08-05
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.
J.Am.Chem.Soc., 137, 2015
5W3Q
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L28F E.COLI DHFR IN COMPLEX WITH NADPH
Descriptor:Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION
Authors:Oyen, D., Wright, P.E., Wilson, I.A.
Deposit date:2017-06-08
Release date:2017-08-09
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion.
J. Am. Chem. Soc., 139, 2017
6VSR
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CRYSTAL STRUCTURE OF MACAQUE ANTI-HIV-1 ANTIBODY RM20F
Descriptor:RM20F Fab Heavy Chain, RM20F Fab Light Chain, SULFATE ION
Authors:Oyen, D., Yuan, M., Wilson, I.A.
Deposit date:2020-02-11
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.176 Å)
Cite:Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Plos Pathog., 16, 2020
6BQB
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MGG4 FAB IN COMPLEX WITH PEPTIDE
Descriptor:MGG4 Fab light chain, MGG4 Fab heavy chain, N-terminal junction peptide, ...
Authors:Oyen, D., Tan, J., Lanzavecchia, A., Wilson, I.A.
Deposit date:2017-11-27
Release date:2018-03-07
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.
Nat. Med., 24, 2018
6UC5
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FAB397 IN COMPLEX WITH NPNA PEPTIDE
Descriptor:Fab397 heavy chain, Fab397 light chain, NPNA peptide
Authors:Pholcharee, T., Oyen, D., Wilson, I.A.
Deposit date:2019-09-13
Release date:2020-01-08
Last modified:2020-03-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein.
J.Mol.Biol., 432, 2020
6W00
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CRYSTAL STRUCTURE OF FAB239 IN COMPLEX WITH NPNA2 PEPTIDE FROM CIRCUMSPOROZOITE PROTEIN
Descriptor:Immunoglobulin G-binding protein G, Fab239 light chain, Fab239 heavy chain, ...
Authors:Pholcharee, T., Oyen, D., Wilson, I.A.
Deposit date:2020-02-28
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.853 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
Biorxiv, 2020
6W05
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CRYSTAL STRUCTURE OF FAB356 IN COMPLEX WITH NPNA2 PEPTIDE FROM CIRCUMSPOROZOITE PROTEIN
Descriptor:Fab356 heavy chain, Fab356 light chain, NPNA2 peptide
Authors:Pholcharee, T., Oyen, D., Wilson, I.A.
Deposit date:2020-02-29
Release date:2020-07-29
Method:X-RAY DIFFRACTION (2.516 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
Biorxiv, 2020
6WFW
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CRYSTAL STRUCTURE OF FAB364 IN COMPLEX WITH NPNA2 PEPTIDE FROM CIRCUMSPOROZOITE PROTEIN
Descriptor:Immunoglobulin G-binding protein G, Fab364 heavy chain, Fab364 light chain, ...
Authors:Pholcharee, T., Oyen, D., Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
Biorxiv, 2020
6WFX
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CRYSTAL STRUCTURE OF FAB395 IN COMPLEX WITH NPNA2 PEPTIDE FROM CIRCUMSPOROZOITE PROTEIN
Descriptor:Fab395 heavy chain, Fab395 light chain, NPNA2 peptide
Authors:Pholcharee, T., Oyen, D., Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
Biorxiv, 2020
6WFY
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CRYSTAL STRUCTURE OF FAB224 IN COMPLEX WITH NPNA4 PEPTIDE FROM CIRCUMSPOROZOITE PROTEIN
Descriptor:Fab224 heavy chain, Fab224 light chain, NPNA4 peptide
Authors:Pholcharee, T., Oyen, D., Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.226 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
Biorxiv, 2020
6WFZ
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CRYSTAL STRUCTURE OF FAB399 IN COMPLEX WITH NPNA3 PEPTIDE FROM CIRCUMSPOROZOITE PROTEIN
Descriptor:Fab399 heavy chain, Fab399 light chain, NPNA3 peptide
Authors:Pholcharee, T., Oyen, D., Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
Biorxiv, 2020
6WG0
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CRYSTAL STRUCTURE OF FAB366 IN COMPLEX WITH NPNA3 PEPTIDE FROM CIRCUMSPOROZOITE PROTEIN
Descriptor:Fab366 heavy chain, Fab366 light chain, NPNA3 peptide
Authors:Pholcharee, T., Oyen, D., Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
Biorxiv, 2020
6WG1
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CRYSTAL STRUCTURE OF FAB399 IN COMPLEX WITH NPNA6 PEPTIDE FROM CIRCUMSPOROZOITE PROTEIN
Descriptor:Fab399 heavy chain, Fab399 light chain, NPNA6 peptide
Authors:Pholcharee, T., Oyen, D., Wilson, I.A.
Deposit date:2020-04-04
Release date:2020-07-29
Method:X-RAY DIFFRACTION (2.086 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
Biorxiv, 2020
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PDB entries from 2020-10-21