4I1N

R104A-ca1697 nanobody binding to the binary DHFR.folate complex

Summary for 4I1N

Related4I13
DescriptorDihydrofolate reductase, Protein ca1697 (nanobody), FOLIC ACID, ... (4 entities in total)
Functional Keywordsalpha/beta fold, immunoglobulin fold, reductase, nadph, folate derivatives, hydride transfer, oxidoreductase-immune system complex, oxidoreductase/immune system
Biological sourceEscherichia coli
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Total number of polymer chains2
Total molecular weight33201.23
Authors
Oyen, D.,Steyaert, J.,Barlow, J.N. (deposition date: 2012-11-21, release date: 2013-11-27)
Primary citation
Oyen, D.,Steyaert, J.,Barlow, J.N.
Exploring an alternative antibody interaction mechanism
To be Published,
Experimental method
X-RAY DIFFRACTION (1.888 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.217100.9%2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution