5CC9

L28F E.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate

Summary for 5CC9

Entry DOI	10.2210/pdb5cc9/pdb
Related	5CCC
Descriptor	Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5,10-DIDEAZATETRAHYDROFOLIC ACID, ... (4 entities in total)
Functional Keywords	folate metabolism, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	19240.22
Authors	Oyen, D.,Wright, P.E. (deposition date: 2015-07-01, release date: 2015-08-05, Last modification date: 2023-09-27)
Primary citation	Oyen, D.,Fenwick, R.B.,Stanfield, R.L.,Dyson, H.J.,Wright, P.E. Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway. J.Am.Chem.Soc., 137:9459-9468, 2015 Cited by PubMed: 26147643 DOI: 10.1021/jacs.5b05707 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.199 Å)

Structure validation