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4H8K
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BU of 4h8k by Molmil
Crystal structure of LC11-RNase H1 in complex with RNA/DNA hybrid
Descriptor: DNA (5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*G)-3'), RNA (5'-R(*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3'), Ribonuclease H
Authors:Nguyen, T.N, You, D.J, Matsumoto, H, Kanaya, E, Kanaya, S.
Deposit date:2012-09-23
Release date:2013-09-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of metagenome-derived LC11-RNase H1 in complex with RNA/DNA hybrid
J.Struct.Biol., 182, 2013
3U3G
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BU of 3u3g by Molmil
Structure of LC11-RNase H1 Isolated from Compost by Metagenomic Approach: Insight into the Structural Bases for Unusual Enzymatic Properties of Sto-RNase H1
Descriptor: CHLORIDE ION, Ribonuclease H, UNKNOWN LIGAND
Authors:Nguyen, T.N, Angkawidjaja, C, Kanaya, E, Koga, Y, Takano, K, Kanaya, S.
Deposit date:2011-10-05
Release date:2012-03-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Activity, stability, and structure of metagenome-derived LC11-RNase H1, a homolog of Sulfolobus tokodaii RNase H1
Protein Sci., 21, 2012
5MTF
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BU of 5mtf by Molmil
A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases
Descriptor: CHLORIDE ION, Rhomboid protease GlpG, inhibitor, ...
Authors:Ticha, A, Stanchev, S, Vinothkumar, K.R, Mikles, D.C, Pachl, P, Svehlova, K, Nguyen, M.T.N, Verhelst, S.H.L, Johnson, D, Bachovchin, D, Lepsik, M, Majer, P, Strisovsky, K.
Deposit date:2017-01-09
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.
Cell Chem Biol, 24, 2017
6D9H
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BU of 6d9h by Molmil
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist
Descriptor: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Draper-Joyce, C.J, Khoshouei, M, Thal, D.M, Liang, Y.-L, Nguyen, A.T.N, Furness, S.G.B, Venugopal, H, Baltos, J, Plitzko, J.M, Danev, R, Baumeister, W, May, L.T, Wootten, D, Sexton, P, Glukhova, A, Christopoulos, A.
Deposit date:2018-04-29
Release date:2018-06-20
Last modified:2018-07-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of the adenosine-bound human adenosine A1receptor-Gicomplex.
Nature, 558, 2018
3KRS
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BU of 3krs by Molmil
Structure of Triosephosphate Isomerase from Cryptosporidium Parvum at 1.55A Resolution
Descriptor: SODIUM ION, Triosephosphate isomerase, UNKNOWN ATOM OR ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-11-19
Release date:2009-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of triosephosphate isomerase from Cryptosporidium parvum.
Acta Crystallogr.,Sect.F, 67, 2011
4Z55
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BU of 4z55 by Molmil
Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378
Descriptor: ALK tyrosine kinase receptor, GLYCEROL, N~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
Authors:Lee, C.C, Spraggon, G.
Deposit date:2015-04-02
Release date:2016-02-03
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
8UYI
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BU of 8uyi by Molmil
Structure of ADP-bound and phosphorylated Pediculus humanus (Ph) PINK1 dimer
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase Pink1, ...
Authors:Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D.
Deposit date:2023-11-13
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
8UYF
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BU of 8uyf by Molmil
Structure of nucleotide-free Pediculus humanus (Ph) PINK1 dimer
Descriptor: Serine/threonine-protein kinase Pink1, mitochondrial
Authors:Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D.
Deposit date:2023-11-13
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
8UYH
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BU of 8uyh by Molmil
Structure of AMP-PNP-bound Pediculus humanus (Ph) PINK1 dimer
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Pink1, ...
Authors:Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D.
Deposit date:2023-11-13
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
7JHX
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BU of 7jhx by Molmil
Crystal structure of hEPG5 LIR/GABARAPL1 complex
Descriptor: Ectopic P granules protein 5 homolog, Gamma-aminobutyric acid receptor-associated protein-like 1, SULFATE ION
Authors:Cheung, Y.W.S, Yip, C.K.
Deposit date:2020-07-21
Release date:2021-03-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Insights on autophagosome-lysosome tethering from structural and biochemical characterization of human autophagy factor EPG5.
Commun Biol, 4, 2021
8D28
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BU of 8d28 by Molmil
Crystal structure of theophylline aptamer in complex with theophylline
Descriptor: MAGNESIUM ION, RNA (33-MER), SODIUM ION, ...
Authors:Menichelli, E, Spraggon, G.
Deposit date:2022-05-28
Release date:2022-11-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Discovery of small molecules that target a tertiary-structured RNA.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D2B
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BU of 8d2b by Molmil
Crystal structure of theophylline aptamer in complex with TAL2
Descriptor: 6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-ol, MAGNESIUM ION, RNA (33-MER), ...
Authors:Menichelli, E, Spraggon, G.
Deposit date:2022-05-28
Release date:2022-11-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Discovery of small molecules that target a tertiary-structured RNA.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D2A
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BU of 8d2a by Molmil
Crystal structure of theophylline aptamer in complex with TAL3
Descriptor: 6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-ol, MAGNESIUM ION, RNA (33-MER), ...
Authors:Menichelli, E, Spraggon, G.
Deposit date:2022-05-28
Release date:2022-11-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Discovery of small molecules that target a tertiary-structured RNA.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D5O
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BU of 8d5o by Molmil
Crystal structure of theophylline aptamer in complex with TAL4
Descriptor: 4-[4-(6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl]butan-1-ol, RNA (33-MER)
Authors:Menichelli, E, Spraggon, G.
Deposit date:2022-06-05
Release date:2022-11-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of small molecules that target a tertiary-structured RNA.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D5L
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BU of 8d5l by Molmil
Crystal structure of theophylline aptamer in complex with TAL1
Descriptor: 4-amino-8-methylpteridine-2,7(1H,8H)-dione, CALCIUM ION, MAGNESIUM ION, ...
Authors:Menichelli, E, Spraggon, G.
Deposit date:2022-06-05
Release date:2022-11-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Discovery of small molecules that target a tertiary-structured RNA.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D29
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BU of 8d29 by Molmil
Crystal structure of theophylline aptamer - apo form
Descriptor: Fab heavy chain, Fab light chain, POTASSIUM ION, ...
Authors:Menichelli, E, Spraggon, G.
Deposit date:2022-05-28
Release date:2022-11-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Discovery of small molecules that target a tertiary-structured RNA.
Proc.Natl.Acad.Sci.USA, 119, 2022
8DO8
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BU of 8do8 by Molmil
Crystal structure ATG9 HDIR in complex with the ATG13:ATG101 HORMA dimer
Descriptor: Autophagy-related protein 101, Autophagy-related protein 13, GLYCEROL
Authors:Buffalo, C.Z, Ren, X, Yokom, A.L, Hurley, J.H.
Deposit date:2022-07-12
Release date:2022-11-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation.
Sci Adv, 9, 2023
8DK7
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BU of 8dk7 by Molmil
Crystal structure of theophylline aptamer soaked with TAL2
Descriptor: FAB heavy chain, FAB light chain, RNA (34-MER)
Authors:Menichelli, E, Spraggon, G.
Deposit date:2022-07-04
Release date:2022-11-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Discovery of small molecules that target a tertiary-structured RNA.
Proc.Natl.Acad.Sci.USA, 119, 2022
5MT7
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BU of 5mt7 by Molmil
Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-VRHA-cmk
Descriptor: ACE-VAL-ARG-HIS-ALA-0QE, Rhomboid protease GlpG
Authors:Vinothkumar, K.R.
Deposit date:2017-01-06
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.
Cell Chem Biol, 24, 2017
5MT6
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BU of 5mt6 by Molmil
Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-phenylethyl-ketoamide
Descriptor: ACE-ARG-VAL-ARG-HIS-ALA-V9C, Rhomboid protease GlpG, nonyl beta-D-glucopyranoside
Authors:Vinothkumar, K.R.
Deposit date:2017-01-06
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.
Cell Chem Biol, 24, 2017
5MT8
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BU of 5mt8 by Molmil
Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-cmk
Descriptor: ACE-ARG-VAL-ARG-HIS-ALA-0QE, CHLORIDE ION, Rhomboid protease GlpG, ...
Authors:Vinothkumar, K.R.
Deposit date:2017-01-06
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.
Cell Chem Biol, 24, 2017
6Y5S
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BU of 6y5s by Molmil
Crystal structure of savinase at cryogenic conditions
Descriptor: CALCIUM ION, SODIUM ION, Subtilisin Savinase
Authors:Wu, S, Moroz, O, Turkenburg, J, Nielsen, J.E, Wilson, K.S, Teilum, K.
Deposit date:2020-02-25
Release date:2020-06-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Conformational heterogeneity of Savinase from NMR, HDX-MS and X-ray diffraction analysis.
Peerj, 8, 2020
5LK6
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BU of 5lk6 by Molmil
Crystal structure of a lipase carboxylesterase from Sulfolobus islandicus
Descriptor: Alpha/beta hydrolase fold-3 domain protein, SULFATE ION
Authors:Schwarz-Linnet, T, Teilum, K, Olsen, J.G.
Deposit date:2016-07-21
Release date:2017-08-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:EstA from Sufolobus islandicus is stabilized by mono-methylation of lysine residues
To Be Published
7LD3
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BU of 7ld3 by Molmil
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand
Descriptor: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A.
Deposit date:2021-01-12
Release date:2021-09-08
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia.
Nature, 597, 2021
7LD4
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BU of 7ld4 by Molmil
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist
Descriptor: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A.
Deposit date:2021-01-12
Release date:2021-09-08
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia.
Nature, 597, 2021

 

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