3KRS
Structure of Triosephosphate Isomerase from Cryptosporidium Parvum at 1.55A Resolution
Summary for 3KRS
| Entry DOI | 10.2210/pdb3krs/pdb |
| Descriptor | Triosephosphate isomerase, SODIUM ION, UNKNOWN ATOM OR ION, ... (4 entities in total) |
| Functional Keywords | ssgcid, sbri, emerald biostructures, university of washington, nih, niaid, triosephosphate isomerase, cryptosporidium parvum, isomerase, structural genomics, seattle structural genomics center for infectious disease |
| Biological source | Cryptosporidium parvum Iowa II |
| Total number of polymer chains | 2 |
| Total formula weight | 59451.02 |
| Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2009-11-19, release date: 2009-12-01, Last modification date: 2023-09-06) |
| Primary citation | Nguyen, T.N.,Abendroth, J.,Leibly, D.J.,Le, K.P.,Guo, W.,Kelley, A.,Stewart, L.,Myler, P.J.,Van Voorhis, W.C. Structure of triosephosphate isomerase from Cryptosporidium parvum. Acta Crystallogr.,Sect.F, 67:1095-1099, 2011 Cited by PubMed Abstract: Cryptosporidium parvum is one of several Cryptosporidium spp. that cause the parasitic infection cryptosporidiosis. Cryptosporidiosis is a diarrheal infection that is spread via the fecal-oral route and is commonly caused by contaminated drinking water. Triosephosphate isomerase is an enzyme that is ubiquitous to all organisms that perform glycolysis. Triosephosphate isomerase catalyzes the formation of glyceraldehyde 3-phosphate from dihydroxyacetone phosphate, which is a critical step to ensure the maximum ATP production per glucose molecule. In this paper, the 1.55 Å resolution crystal structure of the open-loop form of triosephosphate isomerase from C. parvum Iowa II is presented. An unidentified electron density was found in the active site. PubMed: 21904056DOI: 10.1107/S1744309111019178 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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