5MT7

Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-VRHA-cmk

Summary for 5MT7

Entry DOI	10.2210/pdb5mt7/pdb
Descriptor	Rhomboid protease GlpG, ACE-VAL-ARG-HIS-ALA-0QE (3 entities in total)
Functional Keywords	hydrolase, membrane protein, intramembrane protease
Biological source	Escherichia coli K-12 More
Total number of polymer chains	2
Total formula weight	20999.31
Authors	Vinothkumar, K.R. (deposition date: 2017-01-06, release date: 2017-11-15, Last modification date: 2024-01-17)
Primary citation	Ticha, A.,Stanchev, S.,Vinothkumar, K.R.,Mikles, D.C.,Pachl, P.,Began, J.,Skerle, J.,Svehlova, K.,Nguyen, M.T.N.,Verhelst, S.H.L.,Johnson, D.C.,Bachovchin, D.A.,Lepsik, M.,Majer, P.,Strisovsky, K. General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24:1523-1536.e4, 2017 Cited by PubMed: 29107700 DOI: 10.1016/j.chembiol.2017.09.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation