8D5O
Crystal structure of theophylline aptamer in complex with TAL4
Summary for 8D5O
| Entry DOI | 10.2210/pdb8d5o/pdb |
| Descriptor | RNA (33-MER), 4-[4-(6,7-dimethoxyquinazolin-4-yl)piperazin-1-yl]butan-1-ol (2 entities in total) |
| Functional Keywords | rna, aptamer, theophylline |
| Biological source | synthetic construct |
| Total number of polymer chains | 2 |
| Total formula weight | 21967.70 |
| Authors | Menichelli, E.,Spraggon, G. (deposition date: 2022-06-05, release date: 2022-11-30, Last modification date: 2023-10-25) |
| Primary citation | Menichelli, E.,Lam, B.J.,Wang, Y.,Wang, V.S.,Shaffer, J.,Tjhung, K.F.,Bursulaya, B.,Nguyen, T.N.,Vo, T.,Alper, P.B.,McAllister, C.S.,Jones, D.H.,Spraggon, G.,Michellys, P.Y.,Joslin, J.,Joyce, G.F.,Rogers, J. Discovery of small molecules that target a tertiary-structured RNA. Proc.Natl.Acad.Sci.USA, 119:e2213117119-e2213117119, 2022 Cited by PubMed: 36413497DOI: 10.1073/pnas.2213117119 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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