5MTF

A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases

Summary for 5MTF

• Entry DOI: 10.2210/pdb5mtf/pdb
• Descriptor: Rhomboid protease GlpG, inhibitor, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: rhomboid protease, specificity, inhibition, ketoamide, hydrolase
• Biological source: Escherichia coli O45:K1 (strain S88 / ExPEC); More
• Cellular location: Cell inner membrane ; Multi-pass membrane protein : B7MDQ0
• Total number of polymer chains: 2
• Total formula weight: 23930.46

Authors

Ticha, A.,Stanchev, S.,Vinothkumar, K.R.,Mikles, D.C.,Pachl, P.,Svehlova, K.,Nguyen, M.T.N.,Verhelst, S.H.L.,Johnson, D.,Bachovchin, D.,Lepsik, M.,Majer, P.,Strisovsky, K. (deposition date: 2017-01-09, release date: 2017-11-15, Last modification date: 2024-01-17)

• Primary citation: Ticha, A.,Stanchev, S.,Vinothkumar, K.R.,Mikles, D.C.,Pachl, P.,Began, J.,Skerle, J.,Svehlova, K.,Nguyen, M.T.N.,Verhelst, S.H.L.,Johnson, D.C.,Bachovchin, D.A.,Lepsik, M.,Majer, P.,Strisovsky, K.; General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.; Cell Chem Biol, 24:1523-1536.e4, 2017; PubMed: 29107700; DOI: 10.1016/j.chembiol.2017.09.007

Experimental method

X-RAY DIFFRACTION (1.79 Å)