5MTF
A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Rhomboid protease GlpG | polymer | 190 | 21513.6 | 1 | UniProt (B7MDQ0) Pfam (PF01694) UniProt (by SIFTS) (P09391) In PDB | Escherichia coli O45:K1 (strain S88 / ExPEC) | Intramembrane serine protease |
| 2 | C | inhibitor | polymer | 6 | 814.0 | 1 | synthetic construct | ||
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | A | nonyl beta-D-glucopyranoside | non-polymer | 306.4 | 5 | Chemie (BNG) | |||
| 5 | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22327.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1602.9 | |
| All* | Total formula weight | 23930.5 |
