5MTF
A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Rhomboid protease GlpG | polymer | 190 | 21513.6 | 1 | UniProt (B7MDQ0) Pfam (PF01694) UniProt (by SIFTS) (P09391) | Escherichia coli O45:K1 (strain S88 / ExPEC) | Intramembrane serine protease |
| 2 | B (C) | inhibitor | polymer | 6 | 814.0 | 1 | synthetic construct | ||
| 3 | C, D (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) PubChem (312) | |||
| 4 | E, F, G, H, I (A) | nonyl beta-D-glucopyranoside | non-polymer | 306.4 | 5 | Chemie (BNG) PubChem (113558) PubChem (155448) PubChem (57484544) PubChem (67410050) PubChem (67410054) PubChem (67410579) PubChem (67410580) PubChem (67410693) PubChem (67411265) PubChem (67411760) PubChem (67412070) PubChem (67412159) PubChem (67412975) PubChem (67413017) PubChem (71245600) PubChem (9818005) PubChem (92471074) PubChem (92471075) PubChem (11415532) PubChem (94290254) PubChem (94290256) PubChem (12986435) PubChem (95566082) PubChem (95566083) PubChem (14656373) PubChem (101527253) PubChem (129854788) PubChem (131676744) PubChem (136212546) | |||
| 5 | J, K (A, C) | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22327.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1602.9 | |
| All* | Total formula weight | 23930.5 |
