4Z55
Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378
Summary for 4Z55
Entry DOI | 10.2210/pdb4z55/pdb |
Related | 3L9P 3LCS 3LCT 4MKC |
Descriptor | ALK tyrosine kinase receptor, GLYCEROL, N~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine, ... (4 entities in total) |
Functional Keywords | catalytic domain, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : Q9UM73 |
Total number of polymer chains | 1 |
Total formula weight | 38999.80 |
Authors | Lee, C.C.,Spraggon, G. (deposition date: 2015-04-02, release date: 2016-02-03, Last modification date: 2024-03-06) |
Primary citation | Michellys, P.Y.,Chen, B.,Jiang, T.,Jin, Y.,Lu, W.,Marsilje, T.H.,Pei, W.,Uno, T.,Zhu, X.,Wu, B.,Nguyen, T.N.,Bursulaya, B.,Lee, C.,Li, N.,Kim, S.,Tuntland, T.,Liu, B.,Sun, F.,Steffy, A.,Hood, T. Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors. Bioorg.Med.Chem.Lett., 26:1090-1096, 2016 Cited by PubMed: 26750252DOI: 10.1016/j.bmcl.2015.11.049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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