4Z55
Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK tyrosine kinase receptor | polymer | 339 | 38237.9 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (Human) | Anaplastic lymphoma kinase |
| 2 | B, C (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | D (A) | N~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine | non-polymer | 577.7 | 1 | Chemie (4LO) | |||
| 4 | E (A) | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 1072 - 1410 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Gly 1281 | Ser 1281 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38237.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 761.9 | |
| All* | Total formula weight | 38999.8 |
