Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1501 |
| Chain | Residue |
| A | HIS1244 |
| A | PHE1245 |
| A | ILE1246 |
| A | ARG1248 |
| A | ALA1274 |
| A | TYR1278 |
| A | HOH1662 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1502 |
| Chain | Residue |
| A | PHE1174 |
| A | ASN1175 |
| A | ARG1181 |
| A | CYS1182 |
| A | HOH1611 |
| A | HOH1615 |
| A | ILE1171 |
| A | SER1172 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue 4LO A 1503 |
| Chain | Residue |
| A | LEU1122 |
| A | HIS1124 |
| A | GLY1125 |
| A | ALA1148 |
| A | LYS1150 |
| A | LEU1196 |
| A | GLU1197 |
| A | MET1199 |
| A | ALA1200 |
| A | ASP1203 |
| A | SER1206 |
| A | LEU1256 |
| A | ASP1270 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGHGAFGEVYeGqvsgmpndpsplq.....VAVK |
| Chain | Residue | Details |
| A | LEU1122-LYS1150 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDIAARNCLL |
| Chain | Residue | Details |
| A | PHE1245-LEU1257 | |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYragYYR |
| Chain | Residue | Details |
| A | ASP1276-ARG1284 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20632993","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"16878150","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15938644","evidenceCode":"ECO:0000269"}]} |
