5MT6

Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-phenylethyl-ketoamide

Summary for 5MT6

Entry DOI	10.2210/pdb5mt6/pdb
Descriptor	Rhomboid protease GlpG, ACE-ARG-VAL-ARG-HIS-ALA-V9C, nonyl beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywords	hydrolase, membrane protein, intramembrane protease
Biological source	Escherichia coli K-12 More
Total number of polymer chains	2
Total formula weight	21769.89
Authors	Vinothkumar, K.R. (deposition date: 2017-01-06, release date: 2017-11-15, Last modification date: 2024-01-17)
Primary citation	Ticha, A.,Stanchev, S.,Vinothkumar, K.R.,Mikles, D.C.,Pachl, P.,Began, J.,Skerle, J.,Svehlova, K.,Nguyen, M.T.N.,Verhelst, S.H.L.,Johnson, D.C.,Bachovchin, D.A.,Lepsik, M.,Majer, P.,Strisovsky, K. General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24:1523-1536.e4, 2017 Cited by PubMed: 29107700 DOI: 10.1016/j.chembiol.2017.09.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.16 Å)

Structure validation