7LD3

Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand

Summary for 7LD3

• Entry DOI: 10.2210/pdb7ld3/pdb
• EMDB information: 23280
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-2, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
• Functional Keywords: signaling protein, membrane protein, active-state g protein-coupled receptor, adenosine a1 receptor, pam, allosteric modulator
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 130876.13

Authors

Draper-Joyce, C.J.,Danev, R.,Thal, D.M.,Christopoulos, A.,Glukhova, A. (deposition date: 2021-01-12, release date: 2021-09-08, Last modification date: 2021-10-13)

• Primary citation: Draper-Joyce, C.J.,Bhola, R.,Wang, J.,Bhattarai, A.,Nguyen, A.T.N.,Cowie-Kent, I.,O'Sullivan, K.,Chia, L.Y.,Venugopal, H.,Valant, C.,Thal, D.M.,Wootten, D.,Panel, N.,Carlsson, J.,Christie, M.J.,White, P.J.,Scammells, P.,May, L.T.,Sexton, P.M.,Danev, R.,Miao, Y.,Glukhova, A.,Imlach, W.L.,Christopoulos, A.; Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia.; Nature, 597:571-576, 2021; PubMed: 34497422; DOI: 10.1038/s41586-021-03897-2

Experimental method

ELECTRON MICROSCOPY (3.2 Å)