8D2A

Crystal structure of theophylline aptamer in complex with TAL3

Summary for 8D2A

Entry DOI	10.2210/pdb8d2a/pdb
Descriptor	RNA (33-MER), 6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-ol, SODIUM ION, ... (5 entities in total)
Functional Keywords	rna, aptamer, theophylline
Biological source	synthetic construct
Total number of polymer chains	2
Total formula weight	22022.13
Authors	Menichelli, E.,Spraggon, G. (deposition date: 2022-05-28, release date: 2022-11-30, Last modification date: 2023-10-25)
Primary citation	Menichelli, E.,Lam, B.J.,Wang, Y.,Wang, V.S.,Shaffer, J.,Tjhung, K.F.,Bursulaya, B.,Nguyen, T.N.,Vo, T.,Alper, P.B.,McAllister, C.S.,Jones, D.H.,Spraggon, G.,Michellys, P.Y.,Joslin, J.,Joyce, G.F.,Rogers, J. Discovery of small molecules that target a tertiary-structured RNA. Proc.Natl.Acad.Sci.USA, 119:e2213117119-e2213117119, 2022 Cited by PubMed: 36413497 DOI: 10.1073/pnas.2213117119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation