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1TL7
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COMPLEX OF GS- WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'(3')-O-(N-METHYLANTHRANILOYL)-GUANOSINE 5'-TRIPHOSPHATE AND MN
Descriptor:Adenylate cyclase, type V, type II, ...
Authors:Mou, T.C., Gille, A., Seifert, R.J., Sprang, S.R.
Deposit date:2004-06-09
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate.
J.Biol.Chem., 280, 2005
1U0H
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STRUCTURAL BASIS FOR THE INHIBITION OF MAMMALIAN ADENYLYL CYCLASE BY MANT-GTP
Descriptor:Adenylate cyclase, type V, type II, ...
Authors:Mou, T.C., Gille, A., Seifert, R.J., Sprang, S.R.
Deposit date:2004-07-13
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate.
J.Biol.Chem., 280, 2005
5DFS
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CRYSTAL STRUCTURE OF SPIDER MONKEY CYTOCHROME C AT 1.15 ANGSTROM
Descriptor:Cytochrome c, PROTOPORPHYRIN IX CONTAINING FE, 1,2-ETHANEDIOL, ...
Authors:MOU, T.C., McClelland, L.J., Jeakins-Cooley, M.E., Goldes, M.E., SPRANG, S.R., BOWLER, B.E.
Deposit date:2015-08-27
Release date:2016-03-02
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Disruption of a hydrogen bond network in human versus spider monkey cytochrome c affects heme crevice stability.
J.Inorg.Biochem., 158, 2016
5TY3
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CRYSTAL STRUCTURE OF K72A VARIANT OF HUMAN CYTOCHROME C
Descriptor:Cytochrome c, HEME C, SULFATE ION
Authors:Mou, T.C., Nold, S.M., Lei, H., Sprang, S.R., Bowler, B.E.
Deposit date:2016-11-18
Release date:2017-09-06
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Effect of a K72A Mutation on the Structure, Stability, Dynamics, and Peroxidase Activity of Human Cytochrome c.
Biochemistry, 56, 2017
5DFT
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STRUCTURE OF THE ELEVENTH TYPE III DOMAIN FROM HUMAN FIBRONECTIN
Descriptor:Fibronectin, CITRIC ACID
Authors:Rusnac, D.-V., Mou, T.C., Sprang, S.R., Briknarova, K.
Deposit date:2015-08-27
Release date:2016-09-14
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Eleventh Type III Domain from Human Fibronectin
To Be Published
5T7H
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CRYSTAL STRUCTURE OF DIMERIC YEAST ISO-1-CYTOCHROME C WITH CYMAL6
Descriptor:Cytochrome c iso-1, SULFATE ION, 6-cyclohexylhexan-1-ol, ...
Authors:Mcclelland, L., Mou, T.C., Sprang, S.R., Bowler, B.E.
Deposit date:2016-09-05
Release date:2017-03-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Cytochrome c Can Form a Well-Defined Binding Pocket for Hydrocarbons.
J. Am. Chem. Soc., 138, 2016
6AU4
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CRYSTAL STRUCTURE OF THE MAJOR QUADRUPLEX FORMED IN THE HUMAN C-MYC PROMOTER
Descriptor:DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), POTASSIUM ION
Authors:Stump, S., Mou, T.C., Sprang, S.R., Natale, N.R., Beall, H.D.
Deposit date:2017-08-30
Release date:2018-09-12
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene.
PLoS ONE, 13, 2018
3C14
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH PYROPHOSPHATE AND CA
Descriptor:Adenylate cyclase type 5, Adenylate cyclase type 2, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Mou, T.-C., Sprang, S.R.
Deposit date:2008-01-22
Release date:2009-02-03
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structural basis for inhibition of mammalian adenylyl cyclase by calcium.
Biochemistry, 48, 2009
3C15
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH PYROPHOSPHATE AND MG
Descriptor:Adenylate cyclase type 5, Adenylate cyclase type 2, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Mou, T.-C., Sprang, S.R.
Deposit date:2008-01-22
Release date:2009-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Structural basis for inhibition of mammalian adenylyl cyclase by calcium.
Biochemistry, 48, 2009
3C16
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH ADENOSINE-5'-TRIPHOSPHATE AND CA
Descriptor:Adenylate cyclase type 5, Adenylate cyclase type 2, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Mou, T.-C., Sprang, S.R.
Deposit date:2008-01-22
Release date:2009-02-03
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Structural basis for inhibition of mammalian adenylyl cyclase by calcium.
Biochemistry, 48, 2009
3MAA
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH ADENOSINE 5-O-(L-THIOPHOSPHATE) AND LOW CA CONCENTRATION
Descriptor:Adenylate cyclase type 5, Adenylate cyclase type 2, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Mou, T.-C., Sprang, S.R.
Deposit date:2010-03-23
Release date:2010-04-07
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for inhibition of mammalian adenylyl cyclase by calcium.
Biochemistry, 48, 2009
5I56
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AGONIST-BOUND GLUN1/GLUN2A AGONIST BINDING DOMAINS WITH TCN201
Descriptor:Glutamate receptor ionotropic, NMDA 1,Glutamate receptor ionotropic, NMDA 1, ...
Authors:Mou, T.-C., Sprang, S.R., Hansen, K.B.
Deposit date:2016-02-14
Release date:2016-09-07
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
4MU8
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CRYSTAL STRUCTURE OF AN OXIDIZED FORM OF YEAST ISO-1-CYTOCHROME C AT PH 8.8
Descriptor:Cytochrome c iso-1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
Authors:McClelland, L.J., Mou, T.-C., Jeakins-Cooley, M.E., Sprang, S.R., Bowler, B.E.
Deposit date:2013-09-20
Release date:2014-06-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of a mitochondrial cytochrome c conformer competent for peroxidase activity.
Proc.Natl.Acad.Sci.USA, 111, 2014
5DEX
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CRYSTAL STRUCTURE OF GLUN1/GLUN2A NMDA RECEPTOR AGONIST BINDING DOMAINS WITH GLYCINE AND ANTAGONIST, PHENYL-ACEPC
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2A, ...
Authors:Mou, T.-C., Conti, P., Pinto, A., Tamborini, L., Sprang, S.R., Hansen, K.B.
Deposit date:2015-08-26
Release date:2016-09-14
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.
Proc. Natl. Acad. Sci. U.S.A., 2017
5I57
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GLUTAMATE- AND GLYCINE-BOUND GLUN1/GLUN2A AGONIST BINDING DOMAINS
Descriptor:Glutamate receptor ionotropic, NMDA 1,Glutamate receptor ionotropic, NMDA 1, ...
Authors:Mou, T.-C., Sprang, S.R., Hansen, K.B.
Deposit date:2016-02-14
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
5I58
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GLUTAMATE- AND GLYCINE-BOUND GLUN1/GLUN2A AGONIST BINDING DOMAINS WITH MPX-004
Descriptor:Glutamate receptor ionotropic, NMDA 1,Glutamate receptor ionotropic, NMDA 1, ...
Authors:Mou, T.-C., Sprang, S.R., Hansen, K.B.
Deposit date:2016-02-14
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
5I59
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GLUTAMATE- AND GLYCINE-BOUND GLUN1/GLUN2A AGONIST BINDING DOMAINS WITH MPX 007
Descriptor:Glutamate receptor ionotropic, NMDA 1,Glutamate receptor ionotropic, NMDA 1, ...
Authors:Mou, T.-C., Sprang, S.R., Hansen, K.B.
Deposit date:2016-02-14
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
5JTY
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GLUTAMATE- AND DCKA-BOUND GLUN1/GLUN2A AGONIST BINDING DOMAINS WITH MPX-007
Descriptor:Glutamate receptor ionotropic, NMDA 1,Glutamate receptor ionotropic, NMDA 1, ...
Authors:Mou, T.-C., Sprang, S.R., Hansen, K.B.
Deposit date:2016-05-10
Release date:2016-09-21
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.
Neuron, 91, 2016
5VIH
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CRYSTAL STRUCTURE OF GLUN1/GLUN2A NMDA RECEPTOR AGONIST BINDING DOMAINS WITH GLYCINE AND ANTAGONIST, 4-FLUOROPHENYL-ACEPC
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2A, ...
Authors:Mou, T.-C., Conti, P., Pinto, A., Tamborini, L., Sprang, S.R., Hansen, K.B.
Deposit date:2017-04-16
Release date:2017-04-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VII
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CRYSTAL STRUCTURE OF GLUN1/GLUN2A NMDA RECEPTOR AGONIST BINDING DOMAINS WITH GLYCINE AND ANTAGONIST, 4-(3-FLUOROPROPYL)PHENYL-ACEPC
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2A, ...
Authors:Mou, T.-C., Conti, P., Pinto, A., Tamborini, L., Sprang, S.R., Hansen, K.B.
Deposit date:2017-04-16
Release date:2017-04-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.951 Å)
Cite:Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VIJ
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CRYSTAL STRUCTURE OF GLUN1/GLUN2A NMDA RECEPTOR AGONIST BINDING DOMAINS WITH GLYCINE AND ANTAGONIST, 4-BROMOPHENYL-ACEPC
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2A, ...
Authors:Mou, T.-C., Conti, P., Pinto, A., Tamborini, L., Sprang, S.R., Hansen, K.B.
Deposit date:2017-04-16
Release date:2017-04-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5KKE
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CRYSTAL STRUCTURE OF A DOMAIN-SWAPPED DIMER OF YEAST ISO-1-CYTOCHROME C WITH CYMAL5
Descriptor:Cytochrome c iso-1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
Authors:Bowler, B.E., Whitby, F.G.
Deposit date:2016-06-21
Release date:2017-03-22
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Cytochrome c Can Form a Well-Defined Binding Pocket for Hydrocarbons.
J. Am. Chem. Soc., 138, 2016
5KLU
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CRYSTAL STRUCTURE OF A DOMAIN-SWAPPED DIMER OF YEAST ISO-1-CYTOCHROME C WITH OMEGA-UNDECYLENYL-BETA-D-MALTOPYRANOSIDE
Descriptor:Cytochrome c iso-1, PROTOPORPHYRIN IX CONTAINING FE, omega-undecylenyl-beta-D-maltopyranoside, ...
Authors:Bowler, B.E., Whitby, F.G.
Deposit date:2016-06-25
Release date:2017-03-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Cytochrome c Can Form a Well-Defined Binding Pocket for Hydrocarbons.
J. Am. Chem. Soc., 138, 2016
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