6WF3 | | CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH A COFACTOR DERIVED INHIBITOR (COMPOUND 1) | | Descriptor: | N-alpha-acetyltransferase 50, ACE-MET-LEU-GLY-PRO-NH2, COENZYME A | | Authors: | Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E. | | Deposit date: | 2020-04-03 | | Release date: | 2020-07-01 | | Method: | X-RAY DIFFRACTION (2.291 Å) | | Cite: | Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
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6WF5 | | CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH A TRUNCATED COFACTOR DERIVED INHIBITOR (COMPOUND 2) | | Descriptor: | N-alpha-acetyltransferase 50, ACE-MET-LEU-GLY-PRO-NH2, (2R)-2-hydroxy-3,3-dimethyl-N-{3-oxo-3-[(2-sulfanylethyl)amino]propyl}butanamide | | Authors: | Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E. | | Deposit date: | 2020-04-03 | | Release date: | 2020-07-01 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
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6WFG | | CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH AN INHIBITOR (COMPOUND 3) IDENTIFIED USING DNA ENCODED LIBRARY TECHNOLOGY | | Descriptor: | N-alpha-acetyltransferase 50, COENZYME A, (2S)-N-[(2S)-3-[1-(3-tert-butyl-1-methyl-1H-pyrazole-5-carbonyl)piperidin-4-yl]-1-(methylamino)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide | | Authors: | Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E. | | Deposit date: | 2020-04-03 | | Release date: | 2020-07-01 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
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6WFK | | CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH COA AND AN INHIBITOR (COMPOUND 4A) IDENTIFIED USING DNA ENCODED LIBRARY TECHNOLOGY | | Descriptor: | N-alpha-acetyltransferase 50, COENZYME A, (4S)-1-methyl-N-{(3S,5S)-5-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]-1-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]pyrrolidin-3-yl}-2,6-dioxohexahydropyrimidine-4-carboxamide | | Authors: | Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E. | | Deposit date: | 2020-04-03 | | Release date: | 2020-07-01 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
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6WFN | | CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH ACCOA AND AN INHIBITOR (COMPOUND 4A) IDENTIFIED USING DNA ENCODED LIBRARY TECHNOLOGY | | Descriptor: | N-alpha-acetyltransferase 50, ACETYL COENZYME *A, (4S)-1-methyl-N-{(3S,5S)-5-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]-1-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]pyrrolidin-3-yl}-2,6-dioxohexahydropyrimidine-4-carboxamide | | Authors: | Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E. | | Deposit date: | 2020-04-03 | | Release date: | 2020-07-01 | | Method: | X-RAY DIFFRACTION (1.07 Å) | | Cite: | Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
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6WFO | | CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH ACCOA AND AN INHIBITOR (COMPOUND 4B) IDENTIFIED USING DNA ENCODED LIBRARY TECHNOLOGY | | Descriptor: | N-alpha-acetyltransferase 50, ACETYL COENZYME *A, (4S)-1-methyl-N-{(3S,5R)-5-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]-1-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]pyrrolidin-3-yl}-2,6-dioxohexahydropyrimidine-4-carboxamide | | Authors: | Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E. | | Deposit date: | 2020-04-03 | | Release date: | 2020-07-01 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
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6OMM | | CRYO-EM STRUCTURE OF FORMYL PEPTIDE RECEPTOR 2/LIPOXIN A4 RECEPTOR IN COMPLEX WITH GI | | Descriptor: | N-formyl peptide receptor 2, Peptide agonist, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Zhuang, Y., Liu, H., de Waal, P.W., Zhou, X.E., Wang, L., Meng, X., Zhao, G., Kang, Y., Melcher, K., Xu, H.E., Zhang, C. | | Deposit date: | 2019-04-19 | | Release date: | 2020-02-26 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Structure of formylpeptide receptor 2-Gicomplex reveals insights into ligand recognition and signaling.
Nat Commun, 11, 2020
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6PT0 | | CRYO-EM STRUCTURE OF HUMAN CANNABINOID RECEPTOR 2-GI PROTEIN IN COMPLEX WITH AGONIST WIN 55,212-2 | | Descriptor: | Cannabinoid receptor 2, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Xu, T.H., Xing, C., Zhuang, Y., Feng, Z., Zhou, X.E., Chen, M., Wang, L., Meng, X., Xue, Y., Wang, J., Liu, H., McGuire, T., Zhao, G., Melcher, K., Zhang, C., Xu, H.E., Xie, X.Q. | | Deposit date: | 2019-07-14 | | Release date: | 2020-02-12 | | Last modified: | 2020-03-04 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM Structure of the Human Cannabinoid Receptor CB2-GiSignaling Complex.
Cell, 180, 2020
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6J0V | | CRYSTAL STRUCTURE OF YEAST RTT107 | | Descriptor: | Regulator of Ty1 transposition protein 107 | | Authors: | Wan, B., Wu, J., Lei, M. | | Deposit date: | 2018-12-27 | | Release date: | 2019-08-14 | | Last modified: | 2020-02-26 | | Method: | X-RAY DIFFRACTION (2.314 Å) | | Cite: | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6J0W | | CRYSTAL STRUCTURE OF YEAST RTT107 AND NSE6 | | Descriptor: | Regulator of Ty1 transposition protein 107, Peptide from DNA repair protein KRE29 | | Authors: | Wan, B., Wu, J., Lei, M. | | Deposit date: | 2018-12-27 | | Release date: | 2019-08-14 | | Last modified: | 2020-02-26 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6J0X | | CRYSTAL STRUCTURE OF YEAST RTT107 AND MMS22 | | Descriptor: | Regulator of Ty1 transposition protein 107, Peptide from E3 ubiquitin-protein ligase substrate receptor MMS22 | | Authors: | Wan, B., Wu, J., Lei, M. | | Deposit date: | 2018-12-27 | | Release date: | 2019-08-14 | | Last modified: | 2020-02-26 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6J0Y | | CRYSTAL STRUCTURE OF YEAST RTT107 AND SLX4 | | Descriptor: | Regulator of Ty1 transposition protein 107, Peptide from Structure-specific endonuclease subunit SLX4 | | Authors: | Wan, B., Wu, J., Lei, M. | | Deposit date: | 2018-12-27 | | Release date: | 2019-08-14 | | Last modified: | 2020-02-26 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6NCU | | INTERLEUKIN-37 RESIDUES 53-206- DIMER | | Descriptor: | Interleukin-37 | | Authors: | Eisenmesser, E.Z. | | Deposit date: | 2018-12-12 | | Release date: | 2019-03-13 | | Last modified: | 2020-01-22 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Interleukin-37 monomer is the active form for reducing innate immunity.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6CB6 | |
6CB7 | |
5YGI | |
6DJU | | MTB CLPB IN COMPLEX WITH ATPGAMMAS AND CASEIN, CONFORMER 1 | | Descriptor: | Chaperone protein ClpB, casein polyAlanine model, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Yu, H.J., Li, H.L. | | Deposit date: | 2018-05-26 | | Release date: | 2018-09-26 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6DJV | | MTB CLPB IN COMPLEX WITH ATPGAMMAS AND CASEIN, CONFORMER 2 | | Descriptor: | Chaperone protein ClpB, casein polyAlanine model, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Yu, H.J., Li, H.L. | | Deposit date: | 2018-05-26 | | Release date: | 2018-09-26 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6ED3 | | MTB CLPB IN COMPLEX WITH AMPPNP | | Descriptor: | Chaperone protein ClpB | | Authors: | Yu, H.J., Li, H.L. | | Deposit date: | 2018-08-08 | | Release date: | 2018-09-26 | | Last modified: | 2018-10-24 | | Method: | ELECTRON MICROSCOPY (6.3 Å) | | Cite: | ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BR8 | | STRUCTURE OF A6 REVEALS A NOVEL LIPID TRANSPORTER | | Descriptor: | Protein A6 homolog, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE | | Authors: | Deng, J., Peng, S., Pathak, P. | | Deposit date: | 2017-11-30 | | Release date: | 2018-06-20 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BR9 | | STRUCTURE OF A6 REVEALS A NOVEL LIPID TRANSPORTER | | Descriptor: | Protein A6 homolog, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE | | Authors: | Deng, J., Peng, S., Pathak, P. | | Deposit date: | 2017-11-30 | | Release date: | 2018-06-20 | | Last modified: | 2019-12-11 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6CMO | | RHODOPSIN-GI COMPLEX | | Descriptor: | chimera protein of Soluble cytochrome b562 and Rhodopsin, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Kang, Y., Kuybeda, O., de Waal, P.W., Mukherjee, S., Van Eps, N., Dutka, P., Zhou, X.E., Bartesaghi, A., Erramilli, S., Morizumi, T., Gu, X., Yin, Y., Liu, P., Jiang, Y., Meng, X., Zhao, G., Melcher, K., Earnst, O.P., Kossiakoff, A.A., Subramaniam, S., Xu, H.E. | | Deposit date: | 2018-03-05 | | Release date: | 2018-06-20 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature, 558, 2018
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6B9J | | STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV138 | | Descriptor: | IMV membrane protein, Fab vv138 Heavy chain, Fab vv138 Light chain, ... | | Authors: | Zajonc, D.M. | | Deposit date: | 2017-10-10 | | Release date: | 2017-11-22 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
J. Biol. Chem., 293, 2018
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5USH | | STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV66 | | Descriptor: | IMV membrane protein, Fab vv66 heavy chain, Fab vv66 light chain | | Authors: | Zajonc, D.M. | | Deposit date: | 2017-02-13 | | Release date: | 2017-09-20 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
J. Biol. Chem., 293, 2018
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5USL | | STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV304 | | Descriptor: | IMV membrane protein, Fab vv304 Heavy chain, Fab vv304 Light chain | | Authors: | Zajonc, D.M. | | Deposit date: | 2017-02-13 | | Release date: | 2017-09-20 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
J. Biol. Chem., 293, 2018
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