Author results

6WF3
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CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH A COFACTOR DERIVED INHIBITOR (COMPOUND 1)
Descriptor:N-alpha-acetyltransferase 50, ACE-MET-LEU-GLY-PRO-NH2, COENZYME A
Authors:Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E.
Deposit date:2020-04-03
Release date:2020-07-01
Method:X-RAY DIFFRACTION (2.291 Å)
Cite:Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
6WF5
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CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH A TRUNCATED COFACTOR DERIVED INHIBITOR (COMPOUND 2)
Descriptor:N-alpha-acetyltransferase 50, ACE-MET-LEU-GLY-PRO-NH2, (2R)-2-hydroxy-3,3-dimethyl-N-{3-oxo-3-[(2-sulfanylethyl)amino]propyl}butanamide
Authors:Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E.
Deposit date:2020-04-03
Release date:2020-07-01
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
6WFG
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CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH AN INHIBITOR (COMPOUND 3) IDENTIFIED USING DNA ENCODED LIBRARY TECHNOLOGY
Descriptor:N-alpha-acetyltransferase 50, COENZYME A, (2S)-N-[(2S)-3-[1-(3-tert-butyl-1-methyl-1H-pyrazole-5-carbonyl)piperidin-4-yl]-1-(methylamino)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide
Authors:Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E.
Deposit date:2020-04-03
Release date:2020-07-01
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
6WFK
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CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH COA AND AN INHIBITOR (COMPOUND 4A) IDENTIFIED USING DNA ENCODED LIBRARY TECHNOLOGY
Descriptor:N-alpha-acetyltransferase 50, COENZYME A, (4S)-1-methyl-N-{(3S,5S)-5-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]-1-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]pyrrolidin-3-yl}-2,6-dioxohexahydropyrimidine-4-carboxamide
Authors:Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E.
Deposit date:2020-04-03
Release date:2020-07-01
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
6WFN
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CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH ACCOA AND AN INHIBITOR (COMPOUND 4A) IDENTIFIED USING DNA ENCODED LIBRARY TECHNOLOGY
Descriptor:N-alpha-acetyltransferase 50, ACETYL COENZYME *A, (4S)-1-methyl-N-{(3S,5S)-5-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]-1-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]pyrrolidin-3-yl}-2,6-dioxohexahydropyrimidine-4-carboxamide
Authors:Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E.
Deposit date:2020-04-03
Release date:2020-07-01
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
6WFO
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CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH ACCOA AND AN INHIBITOR (COMPOUND 4B) IDENTIFIED USING DNA ENCODED LIBRARY TECHNOLOGY
Descriptor:N-alpha-acetyltransferase 50, ACETYL COENZYME *A, (4S)-1-methyl-N-{(3S,5R)-5-[4-(methylcarbamoyl)-1,3-thiazol-2-yl]-1-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]pyrrolidin-3-yl}-2,6-dioxohexahydropyrimidine-4-carboxamide
Authors:Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E.
Deposit date:2020-04-03
Release date:2020-07-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
6OMM
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CRYO-EM STRUCTURE OF FORMYL PEPTIDE RECEPTOR 2/LIPOXIN A4 RECEPTOR IN COMPLEX WITH GI
Descriptor:N-formyl peptide receptor 2, Peptide agonist, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Zhuang, Y., Liu, H., de Waal, P.W., Zhou, X.E., Wang, L., Meng, X., Zhao, G., Kang, Y., Melcher, K., Xu, H.E., Zhang, C.
Deposit date:2019-04-19
Release date:2020-02-26
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Structure of formylpeptide receptor 2-Gicomplex reveals insights into ligand recognition and signaling.
Nat Commun, 11, 2020
6PT0
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CRYO-EM STRUCTURE OF HUMAN CANNABINOID RECEPTOR 2-GI PROTEIN IN COMPLEX WITH AGONIST WIN 55,212-2
Descriptor:Cannabinoid receptor 2, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, T.H., Xing, C., Zhuang, Y., Feng, Z., Zhou, X.E., Chen, M., Wang, L., Meng, X., Xue, Y., Wang, J., Liu, H., McGuire, T., Zhao, G., Melcher, K., Zhang, C., Xu, H.E., Xie, X.Q.
Deposit date:2019-07-14
Release date:2020-02-12
Last modified:2020-03-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM Structure of the Human Cannabinoid Receptor CB2-GiSignaling Complex.
Cell, 180, 2020
6J0V
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CRYSTAL STRUCTURE OF YEAST RTT107
Descriptor:Regulator of Ty1 transposition protein 107
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.314 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
6J0W
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CRYSTAL STRUCTURE OF YEAST RTT107 AND NSE6
Descriptor:Regulator of Ty1 transposition protein 107, Peptide from DNA repair protein KRE29
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
6J0X
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CRYSTAL STRUCTURE OF YEAST RTT107 AND MMS22
Descriptor:Regulator of Ty1 transposition protein 107, Peptide from E3 ubiquitin-protein ligase substrate receptor MMS22
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
6J0Y
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CRYSTAL STRUCTURE OF YEAST RTT107 AND SLX4
Descriptor:Regulator of Ty1 transposition protein 107, Peptide from Structure-specific endonuclease subunit SLX4
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
6NCU
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INTERLEUKIN-37 RESIDUES 53-206- DIMER
Descriptor:Interleukin-37
Authors:Eisenmesser, E.Z.
Deposit date:2018-12-12
Release date:2019-03-13
Last modified:2020-01-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Interleukin-37 monomer is the active form for reducing innate immunity.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6CB6
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CRYSTAL STRUCTURE OF VACCINIA VIRUS A6 N-TERMINUS (SPACE GROUP C2)
Descriptor:Protein A6
Authors:Han, Y., Zhang, B., Deng, J.
Deposit date:2018-02-02
Release date:2018-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CB7
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CRYSTAL STRUCTURE OF VACCINIA VIRUS A6 N-TERMINUS (SPACE GROUP C2)
Descriptor:Protein A6, NICKEL (II) ION
Authors:Han, Y., Zhang, B., Deng, J.
Deposit date:2018-02-02
Release date:2018-12-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YGI
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN INHIBITOR THZ93
Descriptor:Farnesyl pyrophosphate synthase, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Li, X.
Deposit date:2017-09-23
Release date:2018-09-26
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.177 Å)
Cite:The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell, 175, 2018
6DJU
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MTB CLPB IN COMPLEX WITH ATPGAMMAS AND CASEIN, CONFORMER 1
Descriptor:Chaperone protein ClpB, casein polyAlanine model, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Yu, H.J., Li, H.L.
Deposit date:2018-05-26
Release date:2018-09-26
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DJV
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MTB CLPB IN COMPLEX WITH ATPGAMMAS AND CASEIN, CONFORMER 2
Descriptor:Chaperone protein ClpB, casein polyAlanine model, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Yu, H.J., Li, H.L.
Deposit date:2018-05-26
Release date:2018-09-26
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6ED3
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MTB CLPB IN COMPLEX WITH AMPPNP
Descriptor:Chaperone protein ClpB
Authors:Yu, H.J., Li, H.L.
Deposit date:2018-08-08
Release date:2018-09-26
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BR8
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STRUCTURE OF A6 REVEALS A NOVEL LIPID TRANSPORTER
Descriptor:Protein A6 homolog, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE
Authors:Deng, J., Peng, S., Pathak, P.
Deposit date:2017-11-30
Release date:2018-06-20
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BR9
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STRUCTURE OF A6 REVEALS A NOVEL LIPID TRANSPORTER
Descriptor:Protein A6 homolog, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE
Authors:Deng, J., Peng, S., Pathak, P.
Deposit date:2017-11-30
Release date:2018-06-20
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CMO
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RHODOPSIN-GI COMPLEX
Descriptor:chimera protein of Soluble cytochrome b562 and Rhodopsin, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Kang, Y., Kuybeda, O., de Waal, P.W., Mukherjee, S., Van Eps, N., Dutka, P., Zhou, X.E., Bartesaghi, A., Erramilli, S., Morizumi, T., Gu, X., Yin, Y., Liu, P., Jiang, Y., Meng, X., Zhao, G., Melcher, K., Earnst, O.P., Kossiakoff, A.A., Subramaniam, S., Xu, H.E.
Deposit date:2018-03-05
Release date:2018-06-20
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature, 558, 2018
6B9J
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STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV138
Descriptor:IMV membrane protein, Fab vv138 Heavy chain, Fab vv138 Light chain, ...
Authors:Zajonc, D.M.
Deposit date:2017-10-10
Release date:2017-11-22
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
J. Biol. Chem., 293, 2018
5USH
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STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV66
Descriptor:IMV membrane protein, Fab vv66 heavy chain, Fab vv66 light chain
Authors:Zajonc, D.M.
Deposit date:2017-02-13
Release date:2017-09-20
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
J. Biol. Chem., 293, 2018
5USL
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STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV304
Descriptor:IMV membrane protein, Fab vv304 Heavy chain, Fab vv304 Light chain
Authors:Zajonc, D.M.
Deposit date:2017-02-13
Release date:2017-09-20
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
J. Biol. Chem., 293, 2018
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167518
數據於2020-08-12公開中