Author results

5CYW
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CRYSTAL STRUCTURE OF VACCINIA VIRUS C7
Descriptor:Interferon antagonist C7, GLYCEROL
Authors:Krumm, B.E., Meng, X., Li, Y., Xiang, Y., Deng, J.
Deposit date:2015-07-30
Release date:2015-11-18
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for antagonizing a host restriction factor by C7 family of poxvirus host-range proteins.
Proc.Natl.Acad.Sci.USA, 112, 2015
5CZ3
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CRYSTAL STRUCTURE OF MYXOMA VIRUS M64
Descriptor:M64R, BETA-MERCAPTOETHANOL
Authors:Krumm, B.E., Meng, X., Li, Y., Xiang, Y., Deng, J.
Deposit date:2015-07-31
Release date:2015-11-18
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for antagonizing a host restriction factor by C7 family of poxvirus host-range proteins.
Proc.Natl.Acad.Sci.USA, 112, 2015
4W60
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THE STRUCTURE OF VACCINA VIRUS H7 PROTEIN DISPLAYS A NOVEL PHOSPHOINOSITIDE BINDING FOLD REQUIRED FOR MEMBRANE BIOGENESIS
Descriptor:Late protein H7
Authors:Kolli, S., Meng, X., Wu, X., Shengjuler, D., Cameron, C.E., Xiang, Y., Deng, J.
Deposit date:2014-08-19
Release date:2014-12-31
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-function analysis of vaccinia virus h7 protein reveals a novel phosphoinositide binding fold essential for poxvirus replication.
J.Virol., 89, 2015
6CMO
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RHODOPSIN-GI COMPLEX
Descriptor:chimera protein of Soluble cytochrome b562 and Rhodopsin, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Kang, Y., Kuybeda, O., de Waal, P.W., Mukherjee, S., Van Eps, N., Dutka, P., Zhou, X.E., Bartesaghi, A., Erramilli, S., Morizumi, T., Gu, X., Yin, Y., Liu, P., Jiang, Y., Meng, X., Zhao, G., Melcher, K., Earnst, O.P., Kossiakoff, A.A., Subramaniam, S., Xu, H.E.
Deposit date:2018-03-05
Release date:2018-06-20
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature, 558, 2018
6OMM
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CRYO-EM STRUCTURE OF FORMYL PEPTIDE RECEPTOR 2/LIPOXIN A4 RECEPTOR IN COMPLEX WITH GI
Descriptor:N-formyl peptide receptor 2, Peptide agonist, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Zhuang, Y., Liu, H., de Waal, P.W., Zhou, X.E., Wang, L., Meng, X., Zhao, G., Kang, Y., Melcher, K., Xu, H.E., Zhang, C.
Deposit date:2019-04-19
Release date:2020-02-26
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Structure of formylpeptide receptor 2-Gicomplex reveals insights into ligand recognition and signaling.
Nat Commun, 11, 2020
3J34
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STRUCTURE OF HIV-1 CAPSID PROTEIN BY CRYO-EM
Descriptor:capsid protein
Authors:Zhao, G., Perilla, J.R., Yufenyuy, E., Meng, X., Chen, B., Ning, J., Ahn, J., Gronenborn, A.M., Schulten, K., Aiken, C., Zhang, P.
Deposit date:2013-02-23
Release date:2013-05-29
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (8.6 Å)
Cite:Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics.
Nature, 497, 2013
3J4F
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STRUCTURE OF HIV-1 CAPSID PROTEIN BY CRYO-EM
Descriptor:capsid protein
Authors:Zhao, G., Perilla, J.R., Meng, X., Schulten, K., Zhang, P.
Deposit date:2013-07-11
Release date:2013-07-24
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (8.6 Å)
Cite:Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics.
Nature, 497, 2013
4XFS
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STRUCTURE OF IL-18 SER MUTANT I
Descriptor:Interleukin-18, DIMETHYL SULFOXIDE, GLYCEROL
Authors:Krumm, B.E., Meng, X., Xiang, Y., Deng, J.
Deposit date:2014-12-28
Release date:2015-06-10
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystallization of interleukin-18 for structure-based inhibitor design.
Acta Crystallogr.,Sect.F, 71, 2015
4XFT
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STRUCTURE OF IL-18 SER MUTANT III
Descriptor:Interleukin-18, DIMETHYL SULFOXIDE
Authors:Krumm, B.E., Meng, X., Xiang, Y., Deng, J.
Deposit date:2014-12-29
Release date:2015-06-10
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallization of interleukin-18 for structure-based inhibitor design.
Acta Crystallogr.,Sect.F, 71, 2015
4XFU
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STRUCTURE OF IL-18 SER MUTANT V
Descriptor:Interleukin-18
Authors:Krumm, B.E., Meng, X., Xiang, Y., Deng, J.
Deposit date:2014-12-29
Release date:2015-06-10
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystallization of interleukin-18 for structure-based inhibitor design.
Acta Crystallogr.,Sect.F, 71, 2015
6PT0
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CRYO-EM STRUCTURE OF HUMAN CANNABINOID RECEPTOR 2-GI PROTEIN IN COMPLEX WITH AGONIST WIN 55,212-2
Descriptor:Cannabinoid receptor 2, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, T.H., Xing, C., Zhuang, Y., Feng, Z., Zhou, X.E., Chen, M., Wang, L., Meng, X., Xue, Y., Wang, J., Liu, H., McGuire, T., Zhao, G., Melcher, K., Zhang, C., Xu, H.E., Xie, X.Q.
Deposit date:2019-07-14
Release date:2020-02-12
Last modified:2020-03-04
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM Structure of the Human Cannabinoid Receptor CB2-GiSignaling Complex.
Cell, 180, 2020
5YGI
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN INHIBITOR THZ93
Descriptor:Farnesyl pyrophosphate synthase, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Li, X.
Deposit date:2017-09-23
Release date:2018-09-26
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.177 Å)
Cite:The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell, 175, 2018
5GQH
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CRYO-EM STRUCTURE OF PAECAS3-ACRF3 COMPLEX
Descriptor:CRISPR-associated nuclease/helicase Cas3 subtype I-F/YPEST, anti-CRISPR protein 3
Authors:Zhang, X., Ma, J., Wang, Y., Wang, J.
Deposit date:2016-08-07
Release date:2016-09-21
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses
Cell Res., 26, 2016
4W5X
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THE STRUCTURE OF VACCINA VIRUS H7 PROTEIN DISPLAYS A NOVEL PHOSPHOINOSITIDE BINDING FOLD REQUIRED FOR MEMBRANE BIOGENESIS
Descriptor:Late protein H7
Authors:Kolli, S., Deng, J.
Deposit date:2014-08-19
Release date:2014-12-31
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Structure-function analysis of vaccinia virus h7 protein reveals a novel phosphoinositide binding fold essential for poxvirus replication.
J.Virol., 89, 2015
4WUM
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X-RAY CRYSTAL STRUCTURE OF CHALCONE SYNTHASE FROM FREESIA HYBRIDA
Descriptor:Chalcone synthase
Authors:Almqvist, J., Jiang, W.S., Wang, L., Huang, Y.
Deposit date:2014-11-02
Release date:2014-11-12
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Molecular and Biochemical Analysis of Chalcone Synthase from Freesia hybrid in Flavonoid Biosynthetic Pathway.
Plos One, 10, 2015
5GNF
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CRYSTAL STRUCTURE OF ANTI-CRISPR PROTEIN ACRF3
Descriptor:Uncharacterized protein AcrF3, CALCIUM ION
Authors:Wang, J., Wang, Y.
Deposit date:2016-07-20
Release date:2016-09-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses
Cell Res., 26, 2016
5IMX
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ANAPLASTIC LYMPHOMA KINASE (ALK) CATALYTIC DOMAIN COMPLEXED WITH NOVEL INHIBITOR 3-SULFONYLPYRAZOL-4-AMINO PYRIMIDINE
Descriptor:ALK tyrosine kinase receptor, 5-chloro-N~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1H-pyrazol-4-yl}pyrimidine-2,4-diamine
Authors:Wang, C., Zhang, P., Dong, J.
Deposit date:2016-03-07
Release date:2016-05-04
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Design and synthesis of novel 3-sulfonylpyrazol-4-amino pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
5JLJ
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CRYSTAL STRUCTURE OF KPT8602 IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y., Chook, Y.M.
Deposit date:2016-04-27
Release date:2016-06-29
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.
Leukemia, 30, 2016
6J0V
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CRYSTAL STRUCTURE OF YEAST RTT107
Descriptor:Regulator of Ty1 transposition protein 107
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.314 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
6J0W
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CRYSTAL STRUCTURE OF YEAST RTT107 AND NSE6
Descriptor:Regulator of Ty1 transposition protein 107, Peptide from DNA repair protein KRE29
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
6J0X
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CRYSTAL STRUCTURE OF YEAST RTT107 AND MMS22
Descriptor:Regulator of Ty1 transposition protein 107, Peptide from E3 ubiquitin-protein ligase substrate receptor MMS22
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
6J0Y
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CRYSTAL STRUCTURE OF YEAST RTT107 AND SLX4
Descriptor:Regulator of Ty1 transposition protein 107, Peptide from Structure-specific endonuclease subunit SLX4
Authors:Wan, B., Wu, J., Lei, M.
Deposit date:2018-12-27
Release date:2019-08-14
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
6WF3
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CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH A COFACTOR DERIVED INHIBITOR (COMPOUND 1)
Descriptor:N-alpha-acetyltransferase 50, ACE-MET-LEU-GLY-PRO-NH2, COENZYME A
Authors:Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E.
Deposit date:2020-04-03
Release date:2020-07-01
Method:X-RAY DIFFRACTION (2.291 Å)
Cite:Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
6WF5
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CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH A TRUNCATED COFACTOR DERIVED INHIBITOR (COMPOUND 2)
Descriptor:N-alpha-acetyltransferase 50, ACE-MET-LEU-GLY-PRO-NH2, (2R)-2-hydroxy-3,3-dimethyl-N-{3-oxo-3-[(2-sulfanylethyl)amino]propyl}butanamide
Authors:Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E.
Deposit date:2020-04-03
Release date:2020-07-01
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
6WFG
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CRYSTAL STRUCTURE OF HUMAN NAA50 IN COMPLEX WITH AN INHIBITOR (COMPOUND 3) IDENTIFIED USING DNA ENCODED LIBRARY TECHNOLOGY
Descriptor:N-alpha-acetyltransferase 50, COENZYME A, (2S)-N-[(2S)-3-[1-(3-tert-butyl-1-methyl-1H-pyrazole-5-carbonyl)piperidin-4-yl]-1-(methylamino)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide
Authors:Greasley, S.E., Feng, J., Deng, Y.-L., Stewart, A.E.
Deposit date:2020-04-03
Release date:2020-07-01
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Characterization of SpecificN-alpha-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library.
Acs Med.Chem.Lett., 11, 2020
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PDB entries from 2020-08-05