Author results

5LBZ
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STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH PACRITINIB
分子名称:Ribosyldihydronicotinamide dehydrogenase [quinone], FLAVIN-ADENINE DINUCLEOTIDE, 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene, ...
著者Schneider, S., Medard, G., Kuster, B.
登録日2016-06-17
公開日2017-11-29
最終更新日2017-12-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献The target landscape of clinical kinase drugs.
Science, 358, 2017
5M5A
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CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR
分子名称:Maternal embryonic leucine zipper kinase, SODIUM ION, CHLORIDE ION, ...
著者Canevari, G., Re Depaolini, S., Casale, E., Felder, E., Kuster, B., Heinzlmeir, S.
登録日2016-10-21
公開日2017-12-06
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The target landscape of clinical kinase drugs.
Science, 358, 2017
5MAF
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CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR
分子名称:Maternal embryonic leucine zipper kinase, DIMETHYL SULFOXIDE, CHLORIDE ION, ...
著者Canevari, G., Re Depaolini, S., Casale, E., Felder, E., Kuster, B., Heinzlmeir, S.
登録日2016-11-03
公開日2017-12-06
最終更新日2017-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The target landscape of clinical kinase drugs.
Science, 358, 2017
5MAG
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CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR
分子名称:Maternal embryonic leucine zipper kinase, ~{N}-[(1~{S})-2-(dimethylamino)-1-phenyl-ethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide, DIMETHYL SULFOXIDE, ...
著者Canevari, G., Re Depaolini, S., Casale, E., Felder, E., Kuster, B., Heinzlmeir, S.
登録日2016-11-03
公開日2017-12-06
最終更新日2017-12-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The target landscape of clinical kinase drugs.
Science, 358, 2017
5MAH
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CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR
分子名称:Maternal embryonic leucine zipper kinase, ~{N}-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide, GLYCEROL, ...
著者Canevari, G., Re Depaolini, S., Casale, E., Felder, E., Kuster, B., Heinzlmeir, S.
登録日2016-11-03
公開日2017-12-06
最終更新日2017-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The target landscape of clinical kinase drugs.
Science, 358, 2017
5MAI
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CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR
分子名称:Maternal embryonic leucine zipper kinase, DIMETHYL SULFOXIDE, 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide
著者Canevari, G., Re Depaolini, S., Casale, E., Felder, E., Kuster, B., Heinzlmeir, S.
登録日2016-11-03
公開日2017-12-06
最終更新日2017-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The target landscape of clinical kinase drugs.
Science, 358, 2017
5I9U
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE
分子名称:Ephrin type-A receptor 2, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.889 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9Y
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH DASATINIB
分子名称:Ephrin type-A receptor 2, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.228 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA4
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH FORETINIB (XL880)
分子名称:Ephrin type-A receptor 2, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.797 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5LBW
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STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH VOLITINIB
分子名称:Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Schneider, S., Medard, G., Kuester, B.
登録日2016-06-17
公開日2017-11-29
最終更新日2017-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The target landscape of clinical kinase drugs.
Science, 358, 2017
5LBY
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STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH CRENOLANIB
分子名称:Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Schneider, S., Medard, G., Kuester, B.
登録日2016-06-17
公開日2017-11-29
最終更新日2017-12-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献The target landscape of clinical kinase drugs.
Science, 358, 2017
5I9V
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH AGS
分子名称:Ephrin type-A receptor 2, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.458 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9W
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH ANP
分子名称:Ephrin type-A receptor 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.359 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9X
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH BOSUTINIB (SKI-606)
分子名称:Ephrin type-A receptor 2, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.427 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9Z
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH DANUSERTIB (PHA739358)
分子名称:Ephrin type-A receptor 2, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA0
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH ALISERTIB (MLN8237)
分子名称:Ephrin type-A receptor 2, alisertib, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.948 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA1
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH MLN8054
分子名称:Ephrin type-A receptor 2, 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (2.036 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA2
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 66
分子名称:Ephrin type-A receptor 2, 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.619 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA3
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH PD173955
分子名称:Ephrin type-A receptor 2, 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.788 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA5
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH GOLVATINIB (E7050)
分子名称:Ephrin type-A receptor 2, golvatinib, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Gande, S.L., Sreeramulu, S., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2016-02-21
公開日2016-11-09
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (1.776 Å)
主引用文献Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5NJZ
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 1G
分子名称:Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-(piperidin-4-ylcarbamoyl)phenyl]amino]-1,3-thiazole-5-carboxamide
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (1.768 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK0
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 1J
分子名称:Ephrin type-A receptor 2, 2-[[3-[(3-azanyl-2,2-dimethyl-propyl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (1.597 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK1
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 1K
分子名称:Ephrin type-A receptor 2, 2-[[3-[(4-azanyl-6-methyl-1,3,5-triazin-2-yl)carbamoyl]phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (1.548 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK2
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 2B
分子名称:Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{R},4~{R})-3-fluoranylpiperidin-4-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (1.649 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
5NK3
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 1L
分子名称:Ephrin type-A receptor 2, ~{N}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{S})-pyrrolidin-3-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL
著者Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.
登録日2017-03-31
公開日2017-06-07
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (1.586 Å)
主引用文献Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChemMedChem, 12, 2017
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