5LBZ

Structure of the human quinone reductase 2 (NQO2) in complex with pacritinib

Summary for 5LBZ

• Entry DOI: 10.2210/pdb5lbz/pdb
• Descriptor: Ribosyldihydronicotinamide dehydrogenase [quinone], FLAVIN-ADENINE DINUCLEOTIDE, 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene, ... (6 entities in total)
• Functional Keywords: quinone reductase 2, kinase inhibitor, pancritinib, ribosyldihydronicotinamide dehydrogenase (nqo2), oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P16083
• Total number of polymer chains: 2
• Total formula weight: 56582.12

Authors

Schneider, S.,Medard, G.,Kuster, B. (deposition date: 2016-06-17, release date: 2017-11-29, Last modification date: 2024-01-10)

• Primary citation: Klaeger, S.,Heinzlmeir, S.,Wilhelm, M.,Polzer, H.,Vick, B.,Koenig, P.A.,Reinecke, M.,Ruprecht, B.,Petzoldt, S.,Meng, C.,Zecha, J.,Reiter, K.,Qiao, H.,Helm, D.,Koch, H.,Schoof, M.,Canevari, G.,Casale, E.,Depaolini, S.R.,Feuchtinger, A.,Wu, Z.,Schmidt, T.,Rueckert, L.,Becker, W.,Huenges, J.,Garz, A.K.,Gohlke, B.O.,Zolg, D.P.,Kayser, G.,Vooder, T.,Preissner, R.,Hahne, H.,Tonisson, N.,Kramer, K.,Gotze, K.,Bassermann, F.,Schlegl, J.,Ehrlich, H.C.,Aiche, S.,Walch, A.,Greif, P.A.,Schneider, S.,Felder, E.R.,Ruland, J.,Medard, G.,Jeremias, I.,Spiekermann, K.,Kuster, B.; The target landscape of clinical kinase drugs.; Science, 358:-, 2017; PubMed: 29191878; DOI: 10.1126/science.aan4368

Experimental method

X-RAY DIFFRACTION (1.4 Å)