5LBZ
Structure of the human quinone reductase 2 (NQO2) in complex with pacritinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ribosyldihydronicotinamide dehydrogenase [quinone] | polymer | 237 | 26775.4 | 2 | UniProt (P16083) Pfam (PF02525) | Homo sapiens (Human) | NRH dehydrogenase [quinone] 2,NRH:quinone oxidoreductase 2,Quinone reductase 2,QR2 |
| 2 | C, H (A, B) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 3 | D, I (A, B) | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene | non-polymer | 472.6 | 2 | Chemie (6T3) | |||
| 4 | E, F, J, K (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | G, L (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | M, N (A, B) | water | water | 18.0 | 427 | Chemie (HOH) |
Sequence modifications
A, B: 0 - 230 (UniProt: P16083)
| PDB | External Database | Details |
|---|---|---|
| His 231 | - | expression tag |
| His 232 | - | expression tag |
| His 233 | - | expression tag |
| His 234 | - | expression tag |
| His 235 | - | expression tag |
| His 236 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53550.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3031.3 | |
| All* | Total formula weight | 56582.1 |
