5LBZ

Structure of the human quinone reductase 2 (NQO2) in complex with pacritinib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Ribosyldihydronicotinamide dehydrogenase [quinone]	polymer	237	26775.4	2	UniProt (P16083) Pfam (PF02525) In PDB	Homo sapiens (Human)	NRH dehydrogenase [quinone] 2,NRH:quinone oxidoreductase 2,Quinone reductase 2,QR2
2	A, B	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
3	A, B	11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene	non-polymer		472.6	2	Chemie (6T3)
4	A, B	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
5	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6		water	water		18.0	427	Chemie (HOH)

Sequence modifications

A, B: 0 - 230 (UniProt: P16083)

PDB	External Database	Details
His 231	-	expression tag
His 232	-	expression tag
His 233	-	expression tag
His 234	-	expression tag
His 235	-	expression tag
His 236	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	53550.8
Non-Polymers*	Number of molecules	10
	Total formula weight	3031.3
All*	Total formula weight	56582.1

*Water molecules are not included.