7Z75

PI3KC2a core in complex with PITCOIN3

Summary for 7Z75

Entry DOI	10.2210/pdb7z75/pdb
Descriptor	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ~{N}-[4-[3-(methylsulfonylamino)phenyl]-1,3-thiazol-2-yl]-2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-ethanamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	pi3kc2 alpha, kinase, transferase
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	1
Total formula weight	103237.85
Authors	Lo, W.T.,Roske, Y.,Daumke, O.,Haucke, V. (deposition date: 2022-03-15, release date: 2022-08-31, Last modification date: 2024-02-07)
Primary citation	Lo, W.T.,Belabed, H.,Kucukdisli, M.,Metag, J.,Roske, Y.,Prokofeva, P.,Ohashi, Y.,Horatscheck, A.,Cirillo, D.,Krauss, M.,Schmied, C.,Neuenschwander, M.,von Kries, J.P.,Medard, G.,Kuster, B.,Perisic, O.,Williams, R.L.,Daumke, O.,Payrastre, B.,Severin, S.,Nazare, M.,Haucke, V. Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha. Nat.Chem.Biol., 19:18-27, 2023 Cited by PubMed: 36109648 DOI: 10.1038/s41589-022-01118-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.59 Å)

Structure validation