7Z75
PI3KC2a core in complex with PITCOIN3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | polymer | 910 | 102486.0 | 1 | UniProt (Q61194) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Mus musculus (house mouse) | PI3K-C2-alpha,PtdIns-3-kinase C2 subunit alpha,Cpk-m,Phosphoinositide 3-kinase-C2-alpha,p170 |
| 2 | B (A) | ~{N}-[4-[3-(methylsulfonylamino)phenyl]-1,3-thiazol-2-yl]-2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-ethanamide | non-polymer | 593.7 | 1 | Chemie (IG3) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | E (A) | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A: 1 - 158 (UniProt: Q61194)
A: 271 - 275 (UniProt: Q61194)
A: 284 - 1018 (UniProt: Q61194)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | Phe 375 | engineered mutation |
| Ala 2 | Glu 376 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 267 | - | linker |
| Ser 268 | - | linker |
| Gly 269 | - | linker |
| Ser 270 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 276 | - | linker |
| Ala 277 | - | linker |
| Gly 278 | - | linker |
| Ala 279 | - | linker |
| Gly 280 | - | linker |
| Ser 281 | - | linker |
| Gly 282 | - | linker |
| Ala 283 | - | linker |
| Gly 286 | Ala 668 | conflict |
| Ala 353 | Phe 735 | conflict |
| Ala 354 | Phe 736 | conflict |
| Ala 427 | Leu 809 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 102486.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 751.8 | |
| All* | Total formula weight | 103237.9 |
