7Z74
PI3KC2a core in complex with PITCOIN2
Summary for 7Z74
Entry DOI | 10.2210/pdb7z74/pdb |
Descriptor | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, ~{N}-[4-(3-hydroxyphenyl)-1,3-thiazol-2-yl]-2-[4-oxidanylidene-3-(2-phenylethyl)pteridin-2-yl]sulfanyl-ethanamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | pi3kc2 alpha, kinase, transferase |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 1 |
Total formula weight | 103312.96 |
Authors | Lo, W.T.,Roske, Y.,Daumke, O.,Haucke, V. (deposition date: 2022-03-15, release date: 2022-08-31, Last modification date: 2024-01-31) |
Primary citation | Lo, W.T.,Belabed, H.,Kucukdisli, M.,Metag, J.,Roske, Y.,Prokofeva, P.,Ohashi, Y.,Horatscheck, A.,Cirillo, D.,Krauss, M.,Schmied, C.,Neuenschwander, M.,von Kries, J.P.,Medard, G.,Kuster, B.,Perisic, O.,Williams, R.L.,Daumke, O.,Payrastre, B.,Severin, S.,Nazare, M.,Haucke, V. Development of selective inhibitors of phosphatidylinositol 3-kinase C2 alpha. Nat.Chem.Biol., 19:18-27, 2023 Cited by PubMed: 36109648DOI: 10.1038/s41589-022-01118-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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