5MAG
Crystal structure of MELK in complex with an inhibitor
Summary for 5MAG
Entry DOI | 10.2210/pdb5mag/pdb |
Descriptor | Maternal embryonic leucine zipper kinase, PF-3758309, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, complex, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Peripheral membrane protein : Q14680 |
Total number of polymer chains | 1 |
Total formula weight | 40881.39 |
Authors | Canevari, G.,Re Depaolini, S.,Casale, E.,Felder, E.,Kuster, B.,Heinzlmeir, S. (deposition date: 2016-11-03, release date: 2017-12-06, Last modification date: 2024-05-01) |
Primary citation | Klaeger, S.,Heinzlmeir, S.,Wilhelm, M.,Polzer, H.,Vick, B.,Koenig, P.A.,Reinecke, M.,Ruprecht, B.,Petzoldt, S.,Meng, C.,Zecha, J.,Reiter, K.,Qiao, H.,Helm, D.,Koch, H.,Schoof, M.,Canevari, G.,Casale, E.,Depaolini, S.R.,Feuchtinger, A.,Wu, Z.,Schmidt, T.,Rueckert, L.,Becker, W.,Huenges, J.,Garz, A.K.,Gohlke, B.O.,Zolg, D.P.,Kayser, G.,Vooder, T.,Preissner, R.,Hahne, H.,Tonisson, N.,Kramer, K.,Gotze, K.,Bassermann, F.,Schlegl, J.,Ehrlich, H.C.,Aiche, S.,Walch, A.,Greif, P.A.,Schneider, S.,Felder, E.R.,Ruland, J.,Medard, G.,Jeremias, I.,Spiekermann, K.,Kuster, B. The target landscape of clinical kinase drugs. Science, 358:-, 2017 Cited by PubMed: 29191878DOI: 10.1126/science.aan4368 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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