8QVU
Crystal Structure of ligand ACBI3 in complex with KRAS G12D C118S GDP and pVHL:ElonginC:ElonginB complex
Summary for 8QVU
Entry DOI | 10.2210/pdb8qvu/pdb |
Descriptor | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (9 entities in total) |
Functional Keywords | ternary complex, protac, degrader, e3 ligase, ligase, gene regulation |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 139879.16 |
Authors | Wijaya, A.J.,Zollman, D.,Farnaby, W.,Ciulli, A. (deposition date: 2023-10-18, release date: 2023-12-06, Last modification date: 2024-09-11) |
Primary citation | Popow, J.,Farnaby, W.,Gollner, A.,Kofink, C.,Fischer, G.,Wurm, M.,Zollman, D.,Wijaya, A.,Mischerikow, N.,Hasenoehrl, C.,Prokofeva, P.,Arnhof, H.,Arce-Solano, S.,Bell, S.,Boeck, G.,Diers, E.,Frost, A.,Goodwin-Tindall, J.,Karolyi-Oezguer, J.,Khan, S.,Klawatsch, T.,Koegl, M.,Kousek, R.,Kratochvil, B.,Kropatsch, K.,Lauber, A.,McLennan, R.,Olt, S.,Peter, D.,Petermann, O.,Roessler, V.,Stolt-Bergner, P.,Strack, P.,Strauss, E.,Trainor, N.,Vetma, V.,Whitworth, C.,Zhong, S.,Quant, J.,Weinstabl, H.,Kuster, B.,Ettmayer, P.,Ciulli, A. Targeting cancer with small molecule pan-KRAS degraders Science, 2024 Cited by DOI: 10.1126/science.adm8684PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
Download full validation report