Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8QVU

Crystal Structure of ligand ACBI3 in complex with KRAS G12D C118S GDP and pVHL:ElonginC:ElonginB complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000165	biological_process	MAPK cascade
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005741	cellular_component	mitochondrial outer membrane
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0007165	biological_process	signal transduction
A	0007265	biological_process	Ras protein signal transduction
A	0008283	biological_process	cell population proliferation
A	0008542	biological_process	visual learning
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0010467	biological_process	gene expression
A	0010628	biological_process	positive regulation of gene expression
A	0012505	cellular_component	endomembrane system
A	0014009	biological_process	glial cell proliferation
A	0016020	cellular_component	membrane
A	0016601	biological_process	Rac protein signal transduction
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0021897	biological_process	forebrain astrocyte development
A	0030036	biological_process	actin cytoskeleton organization
A	0030857	biological_process	negative regulation of epithelial cell differentiation
A	0032228	biological_process	regulation of synaptic transmission, GABAergic
A	0035022	biological_process	positive regulation of Rac protein signal transduction
A	0035914	biological_process	skeletal muscle cell differentiation
A	0043495	molecular_function	protein-membrane adaptor activity
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0044877	molecular_function	protein-containing complex binding
A	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
A	0048873	biological_process	homeostasis of number of cells within a tissue
A	0051146	biological_process	striated muscle cell differentiation
A	0051402	biological_process	neuron apoptotic process
A	0060252	biological_process	positive regulation of glial cell proliferation
A	0060441	biological_process	epithelial tube branching involved in lung morphogenesis
A	0060509	biological_process	type I pneumocyte differentiation
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000902	biological_process	cell morphogenesis
B	0003711	molecular_function	transcription elongation factor activity
B	0003714	molecular_function	transcription corepressor activity
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006508	biological_process	proteolysis
B	0008285	biological_process	negative regulation of cell population proliferation
B	0009968	biological_process	negative regulation of signal transduction
B	0010468	biological_process	regulation of gene expression
B	0010507	biological_process	negative regulation of autophagy
B	0010629	biological_process	negative regulation of gene expression
B	0016567	biological_process	protein ubiquitination
B	0019899	molecular_function	enzyme binding
B	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
B	0043066	biological_process	negative regulation of apoptotic process
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043232	cellular_component	intracellular non-membrane-bounded organelle
B	0045597	biological_process	positive regulation of cell differentiation
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0046426	biological_process	negative regulation of receptor signaling pathway via JAK-STAT
B	0050821	biological_process	protein stabilization
B	0060090	molecular_function	molecular adaptor activity
B	0071456	biological_process	cellular response to hypoxia
B	0140297	molecular_function	DNA-binding transcription factor binding
B	1900037	biological_process	regulation of cellular response to hypoxia
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1990000	biological_process	amyloid fibril formation
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0030891	cellular_component	VCB complex
D	0070449	cellular_component	elongin complex
E	0000139	cellular_component	Golgi membrane
E	0000165	biological_process	MAPK cascade
E	0001934	biological_process	positive regulation of protein phosphorylation
E	0003924	molecular_function	GTPase activity
E	0003925	molecular_function	G protein activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005741	cellular_component	mitochondrial outer membrane
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0007165	biological_process	signal transduction
E	0007265	biological_process	Ras protein signal transduction
E	0008283	biological_process	cell population proliferation
E	0008542	biological_process	visual learning
E	0009898	cellular_component	cytoplasmic side of plasma membrane
E	0010467	biological_process	gene expression
E	0010628	biological_process	positive regulation of gene expression
E	0012505	cellular_component	endomembrane system
E	0014009	biological_process	glial cell proliferation
E	0016020	cellular_component	membrane
E	0016601	biological_process	Rac protein signal transduction
E	0016787	molecular_function	hydrolase activity
E	0019003	molecular_function	GDP binding
E	0021897	biological_process	forebrain astrocyte development
E	0030036	biological_process	actin cytoskeleton organization
E	0030857	biological_process	negative regulation of epithelial cell differentiation
E	0032228	biological_process	regulation of synaptic transmission, GABAergic
E	0035022	biological_process	positive regulation of Rac protein signal transduction
E	0035914	biological_process	skeletal muscle cell differentiation
E	0043495	molecular_function	protein-membrane adaptor activity
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	0044877	molecular_function	protein-containing complex binding
E	0048169	biological_process	regulation of long-term neuronal synaptic plasticity
E	0048873	biological_process	homeostasis of number of cells within a tissue
E	0051146	biological_process	striated muscle cell differentiation
E	0051402	biological_process	neuron apoptotic process
E	0060252	biological_process	positive regulation of glial cell proliferation
E	0060441	biological_process	epithelial tube branching involved in lung morphogenesis
E	0060509	biological_process	type I pneumocyte differentiation
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000902	biological_process	cell morphogenesis
F	0003711	molecular_function	transcription elongation factor activity
F	0003714	molecular_function	transcription corepressor activity
F	0004842	molecular_function	ubiquitin-protein transferase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005783	cellular_component	endoplasmic reticulum
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006508	biological_process	proteolysis
F	0008285	biological_process	negative regulation of cell population proliferation
F	0009968	biological_process	negative regulation of signal transduction
F	0010468	biological_process	regulation of gene expression
F	0010507	biological_process	negative regulation of autophagy
F	0010629	biological_process	negative regulation of gene expression
F	0016567	biological_process	protein ubiquitination
F	0019899	molecular_function	enzyme binding
F	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
F	0043066	biological_process	negative regulation of apoptotic process
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043232	cellular_component	intracellular non-membrane-bounded organelle
F	0045597	biological_process	positive regulation of cell differentiation
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0046426	biological_process	negative regulation of receptor signaling pathway via JAK-STAT
F	0050821	biological_process	protein stabilization
F	0060090	molecular_function	molecular adaptor activity
F	0071456	biological_process	cellular response to hypoxia
F	0140297	molecular_function	DNA-binding transcription factor binding
F	1900037	biological_process	regulation of cellular response to hypoxia
F	1904262	biological_process	negative regulation of TORC1 signaling
F	1990000	biological_process	amyloid fibril formation
F	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0030891	cellular_component	VCB complex
H	0070449	cellular_component	elongin complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:22431598, ECO:0000269\|PubMed:22566140

Chain	Residue	Details
E	GLY10
E	VAL29
E	ALA59
E	ASN116
A	GLY10
A	VAL29
A	ALA59
A	ASN116

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269\|Ref.17

Chain	Residue	Details
E	MET1
A	MET1

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269\|Ref.17

Chain	Residue	Details
E	THR2
A	THR2

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:22711838

Chain	Residue	Details
E	LYS104
A	LYS104

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Cysteine methyl ester => ECO:0000269\|PubMed:27791178, ECO:0007744\|PDB:5TAR, ECO:0007744\|PDB:5TB5

Chain	Residue	Details
E	VAL186
A	VAL186

site_id	SWS_FT_FI6
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000305\|PubMed:29239724

Chain	Residue	Details
E	LYS180
A	LYS180

site_id	SWS_FT_FI7
Number of Residues	2
Details	LIPID: N6-palmitoyl lysine => ECO:0000269\|PubMed:29239724

Chain	Residue	Details
E	LYS182
A	LYS182

site_id	SWS_FT_FI8
Number of Residues	4
Details	LIPID: N6-palmitoyl lysine => ECO:0000305\|PubMed:29239724

Chain	Residue	Details
E	LYS184
E	CYS185
A	LYS184
A	CYS185

site_id	SWS_FT_FI9
Number of Residues	2
Details	LIPID: S-farnesyl cysteine => ECO:0000269\|PubMed:27791178, ECO:0000305\|PubMed:24415755, ECO:0007744\|PDB:5TAR, ECO:0007744\|PDB:5TB5

Chain	Residue	Details
E	VAL186
A	VAL186

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269\|PubMed:19744486

Chain	Residue	Details
E	THR35
A	THR35

site_id	SWS_FT_FI11
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305\|PubMed:30442762

Chain	Residue	Details
E	MET170
A	MET170

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)