8QW7

Crystal Structure of compound 4 in complex with KRAS G12V C118S GDP and pVHL:ElonginC:ElonginB

Summary for 8QW7

• Entry DOI: 10.2210/pdb8qw7/pdb
• Descriptor: Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (8 entities in total)
• Functional Keywords: ternary complex, protac, e3 ligase, oncology, oncoprotein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 124473.72

Authors

Zollman, D.,Farnaby, W.,Ciulli, A. (deposition date: 2023-10-18, release date: 2023-12-06)

• Primary citation: Popow, J.,Farnaby, W.,Gollner, A.,Kofink, C.,Fischer, G.,Wurm, M.,Zollman, D.,Wijaya, A.,Mischerikow, N.,Hasenoehrl, C.,Prokofeva, P.,Arnhof, H.,Arce-Solano, S.,Bell, S.,Boeck, G.,Diers, E.,Frost, A.,Goodwin-Tindall, J.,Karolyi-Oezguer, J.,Khan, S.,Klawatsch, T.,Koegl, M.,Kousek, R.,Kratochvil, B.,Kropatsch, K.,Lauber, A.,McLennan, R.,Olt, S.,Peter, D.,Petermann, O.,Roessler, V.,Stolt-Bergner, P.,Strack, P.,Strauss, E.,Trainor, N.,Vetma, V.,Whitworth, C.,Zhong, S.,Quant, J.,Weinstabl, H.,Kuster, B.,Ettmayer, P.,Ciulli, A.; Targeting cancer with small molecule pan-KRAS degraders; Biorxiv, 2023; DOI: 10.1101/2023.10.24.563163

Experimental method

X-RAY DIFFRACTION (2.36 Å)