7A4Q

The Crystal structure of RO4613269 bound to CK2alpha

Summary for 7A4Q

Entry DOI	10.2210/pdb7a4q/pdb
Descriptor	Casein kinase II subunit alpha, 2-methoxyimino-5-(quinolin-6-ylmethyl)-1,3-thiazol-4-one (3 entities in total)
Functional Keywords	selective kinase inhibitors, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	39231.65
Authors	Brear, P.,Hyvonen, M. (deposition date: 2020-08-20, release date: 2022-06-08, Last modification date: 2024-01-31)
Primary citation	Reinecke, M.,Brear, P.,Vornholz, L.,Berger, B.T.,Seefried, F.,Wilhelm, S.,Samaras, P.,Gyenis, L.,Litchfield, D.W.,Medard, G.,Muller, S.,Ruland, J.,Hyvonen, M.,Wilhelm, M.,Kuster, B. Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors. Nat.Chem.Biol., 2023 Cited by PubMed: 37904048 DOI: 10.1038/s41589-023-01459-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation