1R4M | | APPBP1-UBA3-NEDD8, AN E1-UBIQUITIN-LIKE PROTEIN COMPLEX | | Descriptor: | amyloid beta precursor protein-binding protein 1, ubiquitin-activating enzyme E1C, Ubiquitin-like protein NEDD8, ... | | Authors: | Walden, H., Podgorski, M.S., Holton, J.M., Schulman, B.A. | | Deposit date: | 2003-10-07 | | Release date: | 2003-12-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Mol.Cell, 12, 2003
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1R4N | | APPBP1-UBA3-NEDD8, AN E1-UBIQUITIN-LIKE PROTEIN COMPLEX WITH ATP | | Descriptor: | amyloid beta precursor protein-binding protein 1, ubiquitin-activating enzyme E1C, Ubiquitin-like protein NEDD8, ... | | Authors: | Walden, H., Podgorski, M.S., Holton, J.M., Schulman, B.A. | | Deposit date: | 2003-10-07 | | Release date: | 2003-12-23 | | Last modified: | 2017-02-01 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
Mol.Cell, 12, 2003
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1TT5 | | STRUCTURE OF APPBP1-UBA3-UBC12N26: A UNIQUE E1-E2 INTERACTION REQUIRED FOR OPTIMAL CONJUGATION OF THE UBIQUITIN-LIKE PROTEIN NEDD8 | | Descriptor: | amyloid protein-binding protein 1, ubiquitin-activating enzyme E1C isoform 1, Ubiquitin-conjugating enzyme E2 M, ... | | Authors: | Huang, D.T., Miller, D.W., Mathew, R., Cassell, R., Holton, J.M., Roussel, M.F., Schulman, B.A. | | Deposit date: | 2004-06-21 | | Release date: | 2004-09-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
Nat.Struct.Mol.Biol., 11, 2004
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1Y8X | | STRUCTURAL BASIS FOR RECRUITMENT OF UBC12 BY AN E2-BINDING DOMAIN IN NEDD8'S E1 | | Descriptor: | Ubiquitin-conjugating enzyme E2 M, Ubiquitin-activating enzyme E1C | | Authors: | Huang, D.T., Paydar, A., Zhuang, M., Waddell, M.B., Holton, J.M., Schulman, B.A. | | Deposit date: | 2004-12-13 | | Release date: | 2005-02-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
Mol.Cell, 17, 2005
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2NVU | | STRUCTURE OF APPBP1-UBA3~NEDD8-NEDD8-MGATP-UBC12(C111A), A TRAPPED UBIQUITIN-LIKE PROTEIN ACTIVATION COMPLEX | | Descriptor: | NEDD8-activating enzyme E1 regulatory subunit, Maltose binding protein/NEDD8-activating enzyme E1 catalytic subunit chimera, NEDD8-conjugating enzyme Ubc12, ... | | Authors: | Huang, D.T., Hunt, H.W., Zhuang, M., Ohi, M.D., Holton, J.M., Schulman, B.A. | | Deposit date: | 2006-11-13 | | Release date: | 2007-01-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
Nature, 445, 2007
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3FN1 | | E2-RING EXPANSION OF THE NEDD8 CASCADE CONFERS SPECIFICITY TO CULLIN MODIFICATION. | | Descriptor: | NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F | | Authors: | Huang, D.T., Ayrault, O., Hunt, H.W., Taherbhoy, A.M., Duda, D.M., Scott, D.C., Borg, L.A., Neale, G., Murray, P.J., Roussel, M.F., Schulman, B.A. | | Deposit date: | 2008-12-22 | | Release date: | 2009-03-17 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Mol.Cell, 33, 2009
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3ONG | | CRYSTAL STRUCTURE OF UBA2UFD-UBC9: INSIGHTS INTO E1-E2 INTERACTIONS IN SUMO PATHWAYS | | Descriptor: | Ubiquitin-activating enzyme E1-like, SUMO-conjugating enzyme UBC9 | | Authors: | Wang, J., Taherbhoy, A.M., Hunt, H.W., Seyedin, S.N., Miller, D.W., Huang, D.T., Schulman, B.A. | | Deposit date: | 2010-08-28 | | Release date: | 2011-01-12 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways.
Plos One, 5, 2010
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3ONH | | CRYSTAL STRUCTURE OF UBA2UFD-UBC9: INSIGHTS INTO E1-E2 INTERACTIONS IN SUMO PATHWAYS | | Descriptor: | Ubiquitin-activating enzyme E1-like | | Authors: | Wang, J., Taherbhoy, A.M., Hunt, H.W., Seyedin, S.N., Miller, D.W., Huang, D.T., Schulman, B.A. | | Deposit date: | 2010-08-28 | | Release date: | 2011-01-12 | | Last modified: | 2013-01-23 | | Method: | X-RAY DIFFRACTION (1.601 Å) | | Cite: | Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways.
Plos One, 5, 2010
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2Y1M | | STRUCTURE OF NATIVE C-CBL | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION, CALCIUM ION | | Authors: | Dou, H., Sibbet, G.J., Huang, D.T. | | Deposit date: | 2010-12-08 | | Release date: | 2012-01-18 | | Last modified: | 2012-02-15 | | Method: | X-RAY DIFFRACTION (2.67 Å) | | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
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2Y1N | | STRUCTURE OF C-CBL-ZAP-70 PEPTIDE COMPLEX | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, SYK-RELATED TYROSINE KINASE, ... | | Authors: | Dou, H., Sibbet, G.J., Huang, D.T. | | Deposit date: | 2010-12-08 | | Release date: | 2012-01-18 | | Last modified: | 2012-02-15 | | Method: | X-RAY DIFFRACTION (1.999 Å) | | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
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4A49 | | STRUCTURE OF PHOSPHOTYR371-C-CBL-UBCH5B COMPLEX | | Descriptor: | E3 ubiquitin-protein ligase CBL, Ubiquitin-conjugating enzyme E2 D2, ZINC ION, ... | | Authors: | Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T. | | Deposit date: | 2011-10-07 | | Release date: | 2012-01-25 | | Last modified: | 2018-11-21 | | Method: | X-RAY DIFFRACTION (2.214 Å) | | Cite: | Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
Nat. Struct. Mol. Biol., 19, 2012
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4A4B | | STRUCTURE OF MODIFIED PHOSPHOTYR371-C-CBL-UBCH5B-ZAP-70 COMPLEX | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ... | | Authors: | Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T. | | Deposit date: | 2011-10-08 | | Release date: | 2012-01-25 | | Last modified: | 2012-02-29 | | Method: | X-RAY DIFFRACTION (2.789 Å) | | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
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4A4C | | STRUCTURE OF PHOSPHOTYR371-C-CBL-UBCH5B-ZAP-70 COMPLEX | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ... | | Authors: | Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T. | | Deposit date: | 2011-10-08 | | Release date: | 2012-01-25 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.704 Å) | | Cite: | Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
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4AUQ | | STRUCTURE OF BIRC7-UBCH5B-UB COMPLEX. | | Descriptor: | UBIQUITIN-CONJUGATING ENZYME E2 D2, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 7, POLYUBIQUITIN-C, ... | | Authors: | Dou, H., Buetow, L., Sibbet, G.J., Cameron, K., Huang, D.T. | | Deposit date: | 2012-05-21 | | Release date: | 2012-08-15 | | Last modified: | 2012-09-26 | | Method: | X-RAY DIFFRACTION (2.176 Å) | | Cite: | Birc7-E2 Ubiquitin Conjugate Structure Reveals the Mechanism of Ubiquitin Transfer by a Ring Dimer.
Nat.Struct.Mol.Biol., 19, 2012
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3ZNI | | STRUCTURE OF PHOSPHOTYR363-CBL-B - UBCH5B-UB - ZAP-70 PEPTIDE COMPLEX | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE CBL-B, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ... | | Authors: | Dou, H., Buetow, L., Sibbet, G.J., Cameron, K., Huang, D.T. | | Deposit date: | 2013-02-14 | | Release date: | 2013-07-10 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Essentiality of a Non-Ring Element in Priming Donor Ubiquitin for Catalysis by a Monomeric E3.
Nat.Struct.Mol.Biol., 20, 2013
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4V3K | | RNF38-UBCH5B-UB COMPLEX | | Descriptor: | UBIQUITIN-CONJUGATING ENZYME E2 D2, POLYUBIQUITIN-C, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ... | | Authors: | Buetow, L., Gabrielsen, M., Anthony, N.G., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G.J., Smith, B.O., Huang, D.T. | | Deposit date: | 2014-10-20 | | Release date: | 2015-04-08 | | Last modified: | 2015-04-29 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
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4V3L | | RNF38-UB-UBCH5B-UB COMPLEX | | Descriptor: | UBIQUITIN-CONJUGATING ENZYME E2 D2, POLYUBIQUITIN-C, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ... | | Authors: | Buetow, L., Gabrielsen, M., Anthony, N.G., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G.J., Smith, B.O., Huang, D.T. | | Deposit date: | 2014-10-20 | | Release date: | 2015-04-08 | | Last modified: | 2015-04-29 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
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5E5B | |
5J3X | | STRUCTURE OF C-CBL Y371F | | Descriptor: | E3 ubiquitin-protein ligase CBL, ZINC ION, CALCIUM ION | | Authors: | Huang, D.T., Buetow, L., Dou, H. | | Deposit date: | 2016-03-31 | | Release date: | 2016-09-21 | | Method: | X-RAY DIFFRACTION (2.822 Å) | | Cite: | Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.
Bmc Biol., 14, 2016
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5MNJ | | STRUCTURE OF MDM2-MDMX-UBCH5B-UBIQUITIN COMPLEX | | Descriptor: | Ubiquitin-conjugating enzyme E2 D2, Polyubiquitin-B, E3 ubiquitin-protein ligase Mdm2, ... | | Authors: | Klejnot, M., Huang, D.T. | | Deposit date: | 2016-12-13 | | Release date: | 2017-05-31 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.
Nat. Struct. Mol. Biol., 24, 2017
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5O6S | |
5O6T | | BIRC4 RING IN COMPLEX WITH DIMERIC UBIQUITIN VARIANT | | Descriptor: | E3 ubiquitin-protein ligase XIAP, Polyubiquitin-B, ZINC ION, ... | | Authors: | Gabrielsen, M., Buetow, L., Huang, D.T. | | Deposit date: | 2017-06-07 | | Release date: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
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5O75 | | UBE4B U-BOX DOMAIN | | Descriptor: | Ubiquitin conjugation factor E4 B, SULFATE ION | | Authors: | Gabrielsen, M., Buetow, L., Nakasone, M.A., Huang, D.T. | | Deposit date: | 2017-06-08 | | Release date: | 2017-11-01 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.483 Å) | | Cite: | A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
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5O76 | | STRUCTURE OF PHOSPHOY371 C-CBL IN COMPLEX WITH ZAP70-PEPTIDE AND UBV.PCBL UBIQUITIN VARIANT | | Descriptor: | E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, UbV.pCBL ubiquitin variant, ... | | Authors: | Gabrielsen, M., Buetow, L., Huang, D.T. | | Deposit date: | 2017-06-08 | | Release date: | 2017-11-01 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.473 Å) | | Cite: | A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
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6HPR | |
